Figure 6

Minocycline inhibited radiation-induced apoptosis in newborn neurons and decreased the depletion of total number of newborn neurons. (A) The numbers of DCX+/caspase-3+ cells in the dentate SGZ in irradiated rats at different times after irradiation. * P < 0.05, RN vs RM. (B) Quantification of the total numbers of DCX+ cells in the SGZ in irradiated rats at different times after irradiation. * P < 0.05, RN vs RM. (C) In situ immunohistochemistry images of the dentate SGZ 6 h after WBI. Cell markers are: DCX (a nuclear antigen in new neurons, red), caspase-3 (green) and DAPI (blue). The number of rats: n = 3-4/group.