Table 3 Freedom from new brain metastases (univariate analysis)
At 6 months (%) | At 12 months (%) | P -value | |
|---|---|---|---|
Treatment regimen | |||
Radiosurgery alone (n = 30) | 79 | 68 | |
Radiosurgery + WBI (n = 28) | 96 | 89 | 0.040 |
Radiosurgery dose | |||
<20 Gy (n = 23) | 78 | 74 | |
≥20 Gy (n = 35) | 94 | 81 | 0.72 |
Age | |||
≤59 years (n = 34) | 91 | 88 | |
≥60 years (n = 24) | 83 | 61 | 0.20 |
ECOG performance score | |||
0-1 (n = 40) | 90 | 82 | |
2 (n = 18) | 82 | 66 | 0.012 |
Number of cerebral metastases | |||
1 (n = 46) | 87 | 74 | |
2-3 (n = 12) | 92 | 92 | 0.98 |
Maximum diameter of all brain metastases | |||
≤10 mm (n = 28) | 89 | 81 | |
≥11 mm (n = 30) | 86 | 74 | 0.21 |
Site of brain metastases | |||
Supratentorial (n = 39) | 89 | 75 | |
Infratentorial ± supratentorial (n = 19) | 84 | 84 | 0.50 |
Extra-cranial metastases | |||
No (n = 24) | 92 | 73 | |
Yes (n = 34) | 85 | 82 | 0.89 |
Time from breast cancer diagnosis to radiotherapy | |||
≤48 months (n = 30) | 90 | 82 | |
≥49 months (n = 28) | 86 | 73 | 0.33 |