Table 2 POEMS features of the study patients
From: The role of radiotherapy in the management of POEMS syndrome
Characteristic | All (n = 33) | RT ( n = 13) | Non-RT ( n = 20) | p value * |
|---|---|---|---|---|
No. of patients (%) | No. of patients (%) | No. of patients (%) | ||
Polyneuropathy | ||||
Peripheral neuropathy | 33 (100) | 13 (100) | 20 (100) | N/A |
CSF protein >50 mg/dL | 18/20 (90) | 5/5 (100) | 13/15 (87) | 1.00 |
Organomegaly | ||||
Hepatomegaly | 16 (48) | 6 (46) | 10 (50) | 1.000 |
Splenomegaly | 18 (55) | 7 (54) | 11 (55) | 0.614 |
Lymphadenopathy | 15 (45) | 5 (38) | 10 (50) | 0.722 |
Endocrinopathy | ||||
Diabetes mellitus | 6 (18) | 3 (23) | 3 (15) | 0.659 |
Hypothyroidism | 15 (45) | 3 (23) | 12 (60) | 0.072 |
Gonadal axis abnormality | 10 (30) | 3 (23) | 7 (35) | 0.701 |
Adrenal axis abnormality | 8 (24) | 5 (38) | 3 (15) | 0.213 |
Hyperparathyroidism | 0 (0) | 0 (0) | 0 (0) | N/A |
Skin changes | ||||
Hyper-pigmentation | 25 (76) | 11 (85) | 14 (70) | 0.431 |
Acrocyanosis and plethora | 1 (3) | 0 (0) | 1 (5) | 1.000 |
Hemangioma/telangiectasia | 0 (0) | 0 (0) | 0 (0) | N/A |
Hypertrichosis | 16 (48) | 6 (46) | 10 (50) | 1.000 |
Extravascular volume overload | ||||
Peripheral edema | 19 (58) | 6 (46) | 13 (65) | 0.472 |
Ascites | 12 (36) | 1 (8) | 11 (55) | 0.009 |
Pleural effusion | 13 (39) | 1 (8) | 12 (60) | 0.004 |
Pericardial effusion | 7 (21) | 0 (0) | 7 (35) | 0.027 |
Types of bone lesion | ||||
Osteolytic | 4 (12) | 2 (15) | 2 (10) | 0.488 |
Osteosclerotic | 14 (42) | 7 (54) | 7 (35) | |
Mixed | 5 (15) | 4 (31) | 1 (5) | |
No. of bone lesion | ||||
None | 10 (30) | 0 (0) | 10 (50) | 0.008 |
Solitary | 11 (33) | 7 (54) | 4 (20) | |
Multiple | 12 (36) | 6 (46) | 6 (30) |