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Table 2 Multivariate analysis

From: Less advanced disease at initiation of salvage androgen deprivation therapy is associated with decreased mortality following biochemical failure post-salvage radiation therapy

 

Prostate cancer-specific mortality

Overall mortality

Variable

HR (95% CI)

P

HR (95% CI)

P

PSA before SADT

1.0 (1.0–1.0)

0.06

1.0 (1.0–1.0)

0.06

Pre-SADT PSADT <3 months

4.2 (1.6–11.1)

0.004

2.9 (1.3–6.7)

0.01

DM at SADT initiation

1.1 (0.4–3.0)

0.9

0.9 (0.4–2.4)

0.9

Undetectable PSA nadir post-SRT

0.7 (0.2–2.9)

0.7

0.6 (0.2–1.9)

0.4

Total Gleason score

1.2 (0.7–2.1)

0.5

1.0 (0.6–1.7)

1.0

SVI

1.7 (0.6–5.1)

0.3

1.8 (0.7–4.6)

0.2

ECE

0.5 (0.1–2.0)

0.4

0.8 (0.3–2.4)

0.7

SM

1.5 (0.5–4.6)

0.5

1.0 (0.4–2.7)

1.0

ADT during SRT

1.1 (0.3–4.2)

0.9

1.6 (0.5–5.1)

0.4

Start date of SRT

1.0 (1.0–1.0)

0.4

1.0 (1.0–1.0)

0.1

CCMI

1.2 (0.8–1.9)

0.4

1.0 (0.7–1.5)

0.8

IBF <18 months

5.8 (1.3–24.1)

0.02

2.7 (0.9–7.9)

0.07

  1. Abbreviations: HR = hazards ratio, CI = confidence interval, PSA = prostate-specific antigen, SADT = salvage androgen deprivation therapy, DM = distant metastasis, SVI = seminal vesicle invasion, ECE = extracapsular extension, SM = presence of any positive surgical margin, ADT = androgen deprivation therapy, SRT = salvage radiation therapy, CCMI = Charlson Comorbidity Index, IBF = interval to biochemical failure.