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Table 5 Patterns of planning constraints violations in the closed loop validation

From: Assessment of a model based optimization engine for volumetric modulated arc therapy for patients with advanced hepatocellular cancer

Patient

Parameter

Clinical plan

Closed-loop validation

 

1

Normal Liver V30Gy < 30%

31.7%

31.9%

-

2

Normal Liver V30Gy < 30%

30.6%

29.4%

-

3

Normal Liver V30Gy < 30%

34.8%

29.8%

-

4

Spinal cord D1cm3 < 45Gy

45.3%

40.3%

-

Left Kidney V15Gy < 35%

39.2%

14.6%

-

Right kidney V15Gy < 35%

53.8%

39.9%

-

Normal Liver V30Gy < 30%

51.4%

36.9%

-

5

Right kidney V15Gy < 35%

77.4%

38.3%

-

Normal Liver V30Gy < 30%

31.8%

23.3%

-

6

Right kidney V15Gy < 35%

41.6%

19.4%

-

7

Right kidney V15Gy < 35%

43.6%

26.7%

-

Patient

Parameter

Clinical plan

Open-loop validation I

Open-loop validation II

1

Normal Liver V30Gy < 30%

30.5%

27.4%

30.6%

2

Right kidney V15Gy < 35%

46.9%

39.7%

23.6%

3

Right kidney V15Gy < 35%

38.5%

34.8%

34.4%

4

Normal Liver V30Gy < 30%

29.3%

31.0%

29.9%

5

Right kidney V15Gy < 35%

31.8%

36.9%

20.5%

6

Right kidney V15Gy < 35%

38.6%

36.6%

21.5%

PTV D98% > 90%

94.8%

89.3%

89.8%

7

Normal Liver V30Gy < 30%

32.1%

32.5%

33.1%

8

Normal Liver V30Gy < 30%

36.3%

30.0%

39.5%

9

Right kidney V15Gy < 35%

49.9%

26.9%

17.0%

10

Right kidney V15Gy < 35%

38.9%

26.5%

25.0%

11

Right kidney V15Gy < 35%

46.3%

25.6%

22.7%

  1. In bold the parameters that were violated. The patients in the two groups are different.