Table 3 Results of optimal hypofractionation in the three groups divided according to the tumor volumes

Tumor volume (cm³) (median)

10–19.9 (13.4)

20–29.9 (23.8)

30–74.6 (37.5)

Median isodose (%) (range)

57 (50–70)

56 (51–64)

55 (51–64)

Median fraction Number (range)

5 (3–10)

5 (5–10)

5 (5–8)

Median SDE of the max. dose (Gy) (range)

47.2 (36.8-61.9)

48.5 (38.1-61.5)

46.5 (39.7-56.0)

Median V14 (cm³)

5.1

4.4

5.2

(range)

(0.3-6.9)

(0.7-6.1)

(0.4-6.1)

Median KPS

70

70

65

(range)

(50–100)

(50–80)

(50–90)

Tumor response

Reduced (87)

58

17

12

Stable (2)

0

1

1

Enlarged (3)

3

0

0

Marginal recurrences (6)

4/61 (6.6%)

2/18 (11.1%)

0/13 (0%)

Complications (10) (brain edema)

5/61 (8.2%)

4/18 (22.2%)

1/13 (7.7%)