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Table 3 Results of optimal hypofractionation in the three groups divided according to the tumor volumes

From: Optimal hypofractionated conformal radiotherapy for large brain metastases in patients with high risk factors: a single-institutional prospective study

Tumor volume (cm3) (median) 10–19.9 (13.4) 20–29.9 (23.8) 30–74.6 (37.5)
Median isodose (%) (range) 57 (50–70) 56 (51–64) 55 (51–64)
Median fraction Number (range) 5 (3–10) 5 (5–10) 5 (5–8)
Median SDE of the max. dose (Gy) (range) 47.2 (36.8-61.9) 48.5 (38.1-61.5) 46.5 (39.7-56.0)
Median V14 (cm3) 5.1 4.4 5.2
(range) (0.3-6.9) (0.7-6.1) (0.4-6.1)
Median KPS 70 70 65
(range) (50–100) (50–80) (50–90)
Tumor response    
Reduced (87) 58 17 12
Stable (2) 0 1 1
Enlarged (3) 3 0 0
Marginal recurrences (6) 4/61 (6.6%) 2/18 (11.1%) 0/13 (0%)
Complications (10) (brain edema) 5/61 (8.2%) 4/18 (22.2%) 1/13 (7.7%)