Table 2 Univariate and multivariate analyses of grade +2 GI and GU toxicity

Age

0.93

0.89-0.97

<0.001*

0.99

0.93-1.04

0.584

Performance status

1.67

0.73-3.85

0.227

1.84

0.70-4.82

0.218

Comorbidity

1.18

0.75-1.86

0.482

0.88

0.62-1.77

0.878

Smoking

1.05

0.62-1.77

0.853

0.71

0.51-1.58

0.708

3DCRT vs IG-IMRT

12.81

7.84-20.92

<0.001*

11.59

6.67-20.14

<0.001*

Adjuvant ADT

0.31

0.16-0.60

0.001*

0.27

0.13-0.56

<0.001*

GU toxicity

Univariate analysis

Multivariate analysis

Parameter

Hz

95% CI

p-value

Hz

95% CI

p-value

Age

1.00

0.97-1.04

0.869

1.01

0.97-1.05

0.476

Performance status

1.80

0.99-3.24

0.052

1.68

0.89-3.18

0.111

Comorbidity

1.50

1.07-2.11

0.018*

1.50

1.02-2.21

0.038*

Smoking

1.27

0.89-1.81

0.185

1.28

0.88-1.88

0.200

3DCRT vs IG-IMRT

1.58

1.10-2.26

0.013*

1.72

1.11-2.67

0.015*

Adjuvant ADT

0.60

0.34-1.06

0.078

0.57

0.30-1.06

0.075