Radiation Oncology

Table 6 Dosimetric predictors for the development of vaginal ulcer

From: Vaginal tolerance of CT based image-guided high-dose rate interstitial brachytherapy for gynecological malignancies

			2-y incidence ofvaginal ulcer (%)
Parameter	ROC^†AUC^*	Cutoff^¶	2-y incidence ofvaginal ulcer (%)	P value^#
Vaginal wall D_0.5cc^\|\| (EQD₂^††)	0.667	≤195 Gy	0.0	0.058
		>195 Gy	18.5
Vaginal wall D_1cc^\|\| (EQD₂^††)	0.682	≤171 Gy	4.2	0.091
		>171 Gy	20.0
Vaginal wall D_2cc^\|\| (EQD2^††)	0.733	≤145 Gy	3.7	0.026^*
		>145 Gy	23.5
Vaginal wall D_4cc^\|\| (EQD₂^††)	0.618	≤83 Gy	0.0	0.119
		>83 Gy	15.6
Vaginal wall D_6cc^\|\| (EQD₂^††)	0.569	≤86 Gy	5.6	0.323
		>86 Gy	15.4
Vaginal wall D_8cc^\|\| (EQD₂^††)	0.559	≤75 Gy	5.6	0.323
		>75 Gy	15.4

^*AUC: area under the curve.
^†ROC: receiver operator characteristic.
^††EQD2: equivalent dose in 2 Gy fractions.
^||D0.5cc, D1cc, D2cc, D4cc, D6cc, D8cc: most exposed 0.5, 1, 2, 4, 6, and 8 cm3 of tissue.
^¶Cutoff refers to the most predictive value from the AUC of ROC curve.
^# Univariate analysis by log-rank test.

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