Table 1 Novel PET tracers for research and patient care beyond18 F-fluor-desoxyglucose (18 F-FDG) aim at molecular targets such as integrins and somatostatin receptors or a sensitive for up-regulated amino acid turnover or cell membrane synthesis of tumor cells
From: Visualization, imaging and new preclinical diagnostics in radiation oncology
Nuclide | Tracer | Metabolism | Comment |
|---|---|---|---|
11C | 11C - Methionine | Amino acid | Increased amino acid uptake and turnover of tumor cells |
11C -Tyrosine | Amino acid | ||
11C - Leucine | Amino acid | ||
18 F | 18 F - Fluoruracile | Amino acid | |
18 F - Fluorethyltyrosine | Amino acid derivative | Longer half-life of 18 F allows for application of tracers in imaging centers without cyclotron | |
(18 F - FET) | |||
18 F - Fluordesoxyglucose | Glucose metabolism | ||
(18 F – FDG) | |||
18 F –Fluorazomyzinarabinoside | Hypoxia | ||
(18 F – FAZA) | |||
18 F – Fluoromisonidazole | Hypoxia | ||
(18 F – FMISO) | |||
18 F – Fluorthymidine | Proliferation | ||
(18 F – FLT) | |||
18 F - Galacto-RGD | αvβ3-Integrins | ||
[18 F- Arg-Gly-Asp (RGD) Peptide] | |||
18 F - Choline | Prostate carcinoma | ||
18 F - Fluoride | Bone metabolism | ||
68Ga | 68Ga-DOTATOC/DOTA-TATE | Somatostatin receptors (SSR) | SSR-overexpressing tumors |