Table 1 Enriched GO categories among H1299 shRAD9 vs. H1299 differentially expressed genes

Cytoskeletal protein binding

49

0.00001

Actin binding

33

0.0002

GTPase regulator activity

36

0.0009

Growth hormone receptor binding

3

0.001

Phospholipid binding

19

0.002

Phospho-inositide binding

13

0.002

Protein kinase inhibitor activity

7

0.002

Kinase inhibitor activity

7

0.002

GTPase binding

13

0.005

Protein kinase regulator activity

10

0.008

PIP-3,4,5-trisphosphate binding

3

0.009

Cyclin-dependent protein kinase

4

0.01

Microtubule binding

9

0.01

NAD binding

3

0.01

Kinase activity

58

0.02

Oxidoreductase activity

12

0.02

Tubulin binding

11

0.02

Carbohydrate kinase activity

4

0.02

Phospho-transferase activity

51

0.02

Glutathione transferase activity

4

0.02

Transferase activity

63

0.03

De-oxyribonuclease activity

5

0.03

Guanyl-nucleotide exchange factor activity

14

0.03

Rab GTPase activator activity

6

0.04

Heparin binding

10

0.04

B. H1299 shRAD9 vs. H1299, up regulated genes

Gene Ontology Term (molecular functions)

Gene Count

p value

Nor-epinephrine binding

2

0.002

RNA methyl-transferase activity

4

0.002

Myosin binding

4

0.002

Structure-specific DNA binding

9

0.01

Single-stranded DNA binding

5

0.01

Glycoprotein binding

4

0.01

Coenzyme binding

9

0.03

Transcription factor activity

33

0.04