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Table 1 Enriched GO categories among H1299 shRAD9 vs. H1299 differentially expressed genes

From: RAD9 deficiency enhances radiation induced bystander DNA damage and transcriptomal response

A. H1299 shRAD9 vs. H1299, down regulated genes
Gene Ontology Term (molecular functions) Gene Count p value
Cytoskeletal protein binding 49 0.00001
Actin binding 33 0.0002
GTPase regulator activity 36 0.0009
Growth hormone receptor binding 3 0.001
Phospholipid binding 19 0.002
Phospho-inositide binding 13 0.002
Protein kinase inhibitor activity 7 0.002
Kinase inhibitor activity 7 0.002
GTPase binding 13 0.005
Protein kinase regulator activity 10 0.008
PIP-3,4,5-trisphosphate binding 3 0.009
Cyclin-dependent protein kinase 4 0.01
Microtubule binding 9 0.01
NAD binding 3 0.01
Kinase activity 58 0.02
Oxidoreductase activity 12 0.02
Tubulin binding 11 0.02
Carbohydrate kinase activity 4 0.02
Phospho-transferase activity 51 0.02
Glutathione transferase activity 4 0.02
Transferase activity 63 0.03
De-oxyribonuclease activity 5 0.03
Guanyl-nucleotide exchange factor activity 14 0.03
Rab GTPase activator activity 6 0.04
Heparin binding 10 0.04
B. H1299 shRAD9 vs. H1299, up regulated genes
Gene Ontology Term (molecular functions) Gene Count p value
Nor-epinephrine binding 2 0.002
RNA methyl-transferase activity 4 0.002
Myosin binding 4 0.002
Structure-specific DNA binding 9 0.01
Single-stranded DNA binding 5 0.01
Glycoprotein binding 4 0.01
Coenzyme binding 9 0.03
Transcription factor activity 33 0.04