Figure 1

Representative isodose distributions on axial CT images for patient 1. (A) SFIB, (B) SFUD sequential boost and (C) IMPT treatment plans for a central glioma. Targets and normal tissues are represented as color washes. (D) Dose volume histogram for corresponding plans. Solid lines correspond to SFIB, dashed lines to SFUD, and dotted lines to IMPT. Exposure of right and left hippocampi to low and high doses is reduced for SFIB and IMPT plans. (E) Comparison of measured (data points) and calculated (blue lines) depth dose curves for each of three beams employed in the treatment of patient 1. Error bars are fixed values of 3% in the vertical axis and 2 mm in the horizontal axis to help visualizing the difference between measurements and calculations.