From: mRNA-based vaccines synergize with radiation therapy to eradicate established tumors
Pathway/function | Genes upregulated upon vaccination |
---|---|
T cell signaling | Cd8b1 (2.4), Cd8a (2.3), Il12r (1.8), Il2r (1.6), Ifng (1.6), Gzmb (3.0), Gzmk (1.7), Prf1 (2.0), Icos (2.1), Nkg7 (3.5), Stat1 (1.6), Stat4 (1.8) |
NK cell signaling | Klrd1 (2.4), Klrk1 (1.7), Klrc1 (2.9), Nkg7 (3.5), Il12r (1.8), Gzmb (3.0), Gzmk (1.7), Prf1 (2.0), Fcgr3 (1.5), Fcgr4 (1.9) |
Chemotaxis | Ccl3 (1.8), Ccl5 (2.7), Cxcl9 (1.9), Cxcl12 (1.5), Cxcl16 (2.2), Ccr5 (1.6) |
TLR signaling | Tlr7 (2.2), Tlr8 (2.3), Tlr13 (1.8) |
MHC class II presentation | H2-Dma (1.6), H2-Eb2 (1.7), H2-Aa (1.8), Cd74 (1.6), Cathepsins: k,s,c,d,h,l,w,a (1.5-2.1), Lgmn (1.8) |
Complement system | C1qa (1.9), C1qb (1.7), C1qc (2.1), C1r (1.9), C1s (2.7), C2 (2.6), C3 (2.1), C3ar1 (1.7), Cfb (2.7) |
IFN-γ inducible GTPases | Gbp2 (2.2), Gbp3 (1.8), Gbp4 (1.8), Gbp5 (2.0), Gbp6 (1.7) |