Table 4 Relevant plan parameters of 3D-CRT versus TB-IMRT or TB-IMRT versus 7 F-IMRT of the breast or chest wall
Organ | Patient series 1: 3D-CRT versus TB-IMRT | Patient series 2: TB-IMRT versus 7 F-IMRT | ||||||
|---|---|---|---|---|---|---|---|---|
Factor | RT technique | Mean | 95% CI | p-value* | RT technique | Mean | 95% CI | p-value* |
Skin | ||||||||
Mean Dose (percent of the prescribed dose) | ||||||||
3D-CRT | 92.0 | (88.1; 95.9) | n.s. | TB-IMRT | 90.0 | (85.8; 94.2) | <0.01 | |
TB-IMRT | 91.4 | (88.1; 94.8) | 7 F-IMRT | 84.4 | (78.6; 90.3) | |||
Difference (%) | -0.7 | Difference (%) | -6.2 | |||||
PTV | ||||||||
Homogeneity index | ||||||||
3D-CRT | 0.73 | (0.65; 0.80) | n.s. | TB-IMRT | 0.75 | (0.68; 0.81) | n.s. | |
TB-IMRT | 0.73 | (0.67; 0.78) | 7 F-IMRT | 0.72 | (0.63; 0.81) | |||
Difference (%) | 0 | Difference (%) | -4.0 | |||||
Conformity index | ||||||||
3D-CRT | 0.76 | (0.71; 0.81) | <0.001 | TB-IMRT | 0.88 | (0.85; 0.91) | n.s. | |
TB-IMRT | 0.86 | (0.82; 0.89) | 7 F-IMRT | 0.88 | (0.85; 0.91) | |||
Difference (%) | 13.2 | Difference (%) | 0 | |||||
Heart (left-sided PTV) | ||||||||
Mean Dose (cGy) | ||||||||
3D-CRT | 506 | (359; 654) | n.s. | TB-IMRT | 824 | (423; 1224) | 0.01 | |
TB-IMRT | 504 | (380; 628) | 7 F-IMRT | 1647 | (937; 2357) | |||
Difference (%) | -0.4 | Difference (%) | 99.9 | |||||
V70% | ||||||||
3D-CRT | 5.12 | (2.49; 7.75) | 0.03 | TB-IMRT | 9.25 | (1.7; 16.8) | n.s. | |
TB-IMRT | 2.57 | (1.06; 4.09) | 7 F-IMRT | 10.00 | (1.5; 18.5) | |||
Difference (%) | -49.8 | Difference (%) | 8.1 | |||||
Heart (right-sided PTV) | ||||||||
Mean Dose (cGy) | ||||||||
3D-CRT | 157 | (33; 282) | n.s. | TB-IMRT | 78 | (60; 97) | <0.001 | |
TB-IMRT | 149 | (42; 282) | 7 F-IMRT | 704 | (603; 805) | |||
Difference (%) | -5.1 | Difference (%) | 802.6 | |||||
Ipsilateral lung | ||||||||
Mean Dose (cGy) | ||||||||
3D-CRT | 1276 | (1179; 1374) | <0.001 | TB-IMRT | 1031 | (842; 1221) | <0.001 | |
TB-IMRT | 1036 | (943; 1129) | 7 F-IMRT | 1535 | (1382; 1689) | |||
Difference (%) | -18.8 | Difference (%) | 48.9 | |||||
D60% | ||||||||
3D-CRT | 194 | (174; 214) | n.s. | TB-IMRT | 139 | (101; 177) | <0.001 | |
TB-IMRT | 187 | (168; 206) | 7 F-IMRT | 686 | (458; 913) | |||
Difference (%) | -3.6 | Difference (%) | 393.5 | |||||
D30% | ||||||||
3D-CRT | 1327 | (1036; 1618) | <0.001 | TB-IMRT | 934 | (535; 1334) | <0.001 | |
TB-IMRT | 922 | (725; 1119) | 7 F-IMRT | 1775 | (1459; 2091) | |||
Difference (%) | -30.5 | Difference (%) | 90.0 | |||||
Contralateral lung | ||||||||
Mean Dose (cGy) | ||||||||
3D-CRT | 27 | (24; 31) | n.s. | TB-IMRT | 23 | (18; 28) | <0.001 | |
TB-IMRT | 26 | (23; 29) | 7 F-IMRT | 328 | (259; 397) | |||
Difference (%) | -3.7 | Difference (%) | 1326.1 | |||||