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Table 4 Prognostic value of recursive partitioning analysis (RPA) classes

From: Stereotactic radiosurgery (SRS) for brain metastases: a systematic review

Reference Number of patients RPA class I RPA class II RPA class III
Gaspar et al. 1997 [88] 1200 7.1 4.2 2.3
Lorenzoni et al. 2004 [89] 110 (SRS) 27.6 10.7 2.8
Franzin et al. 2009 [90] 185 (SRS) 17.0 10.0 3.0
Likhacheva et al. 2012 [91] 251 (SRS) 38.8 9.4 2.8
Zindler et al. 2013 [92] 380 (SRS) 18.0* 10.0* 4.0*
Sneed et al. 268 (SRS) 14.0 8.2 5.3
2002 [26] 301 (SRS + WBRT) 15.2 7.0 5.5
  1. Median survival in months from different publications.
  2. RPA class I: age <65 years, Karnofsky performance status ≥70, controlled primary tumor, no extracranial metastases.
  3. RPA class II: all other patients.
  4. RPA class III: Karnofsky performance status <70.
  5. SRS: stereotactic radiosurgery, WBRT: whole-brain radiotherapy.
  6. *estimated from Kaplan-Meier graphs included in the publication.