Stereotactic radiosurgery (SRS) for brain metastases: a systematic review

Radiation Oncology

Table 4 Prognostic value of recursive partitioning analysis (RPA) classes

Reference	Number of patients	RPA class I	RPA class II	RPA class III
Gaspar et al. 1997 [88]	1200	7.1	4.2	2.3
Lorenzoni et al. 2004 [89]	110 (SRS)	27.6	10.7	2.8
Franzin et al. 2009 [90]	185 (SRS)	17.0	10.0	3.0
Likhacheva et al. 2012 [91]	251 (SRS)	38.8	9.4	2.8
Zindler et al. 2013 [92]	380 (SRS)	18.0*	10.0*	4.0*
Sneed et al.	268 (SRS)	14.0	8.2	5.3
2002 [26]	301 (SRS + WBRT)	15.2	7.0	5.5

Median survival in months from different publications.
RPA class I: age <65 years, Karnofsky performance status ≥70, controlled primary tumor, no extracranial metastases.
RPA class II: all other patients.
RPA class III: Karnofsky performance status <70.
SRS: stereotactic radiosurgery, WBRT: whole-brain radiotherapy.
*estimated from Kaplan-Meier graphs included in the publication.

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