Skip to main content

Table 2 Radiobiological parameters for each cell line exposed to radiation with increased concentration of nanoparticles

From: Hafnium oxide nanoparticles: toward an in vitropredictive biological effect?

Cell line SF2values (mean ± SD) Control [NBTXR3]
     50 μM 100 μM 200 μM 400 μM 800 μM
   α β α β α β α β α β α β
42-MG-BA 37.3 (±2.53) 0.45 0.02 0.47 0.02 0.48 0.03 0.54 0.03 0.57 0.05 0.60 0.05
HCT 116 22.4 (±9.14) 0.54 0.08† 0.58 0.08† 0.60 0.08† 0.68 0.08† 0.74 0.08† 0.84 0.08†
PANC-1 40.6 (±6.64) 0.43 0.01 0.41 0.02 0.44 0.02 0.50 0.01 0.50 0.02† 0.51 0.02†
HT-1080 38.9 (±1.39) 0.33 0.06 0.37 0.07 0.44 0.08 nd nd 0.55 0.07 nd nd
Hs913T 25.2 (±2.27) 0.68   0.83   0.99   1.07   1.2   1.38  
HT-29 54.1 (±9.50) 0.28 0.05 0.30 0.05 0.39 0.03 0.40 0.03 0.43 0.05† 0.46 0.05†
FaDu 66.0 (±6.78) 0.12 0.06 nd nd 0.26 0.04 nd nd 0.31 0.06 0.28 0.09
CAL-33 64.8 (±2.12) 0.05 0.08 nd nd 0.08 0.08 nd nd 0.16 0.07 0.16 0.09
  1. The LQ model was used to fit the surviving fraction data using GraphPad Prism® V5.0 Software, extracting α and β parameters. : β value was constrained to improve the quality of the fit. The SF2 value for each cell lines is reported.