Hafnium oxide nanoparticles: toward an in vitropredictive biological effect?

Radiation Oncology

Table 2 Radiobiological parameters for each cell line exposed to radiation with increased concentration of nanoparticles

Cell line	SF₂values (mean ± SD)	Control		[NBTXR3]
				50 μM		100 μM		200 μM		400 μM		800 μM
		α	β	α	β	α	β	α	β	α	β	α	β
42-MG-BA	37.3 (±2.53)	0.45	0.02	0.47	0.02	0.48	0.03	0.54	0.03	0.57	0.05	0.60	0.05
HCT 116	22.4 (±9.14)	0.54	0.08†	0.58	0.08†	0.60	0.08†	0.68	0.08†	0.74	0.08†	0.84	0.08†
PANC-1	40.6 (±6.64)	0.43	0.01	0.41	0.02	0.44	0.02	0.50	0.01	0.50	0.02†	0.51	0.02†
HT-1080	38.9 (±1.39)	0.33	0.06	0.37	0.07	0.44	0.08	nd	nd	0.55	0.07	nd	nd
Hs913T	25.2 (±2.27)	0.68		0.83		0.99		1.07		1.2		1.38
HT-29	54.1 (±9.50)	0.28	0.05	0.30	0.05	0.39	0.03	0.40	0.03	0.43	0.05†	0.46	0.05†
FaDu	66.0 (±6.78)	0.12	0.06	nd	nd	0.26	0.04	nd	nd	0.31	0.06	0.28	0.09
CAL-33	64.8 (±2.12)	0.05	0.08	nd	nd	0.08	0.08	nd	nd	0.16	0.07	0.16	0.09

The LQ model was used to fit the surviving fraction data using GraphPad Prism® V5.0 Software, extracting α and β parameters. ^†: β value was constrained to improve the quality of the fit. The SF₂ value for each cell lines is reported.

ISSN: 1748-717X