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Table 1 Disease-related radiotherapy in breast cancer patients with distant metastatic disease

From: Radiotherapy in patients with distant metastatic breast cancer

Variable

n (%)

Entire cohort of the BBCD

1459

Patients with distant metastases (DM)

369 (25.3)

 PMD: DM at initial diagnosis

92 (6.3)

 SMD: DM developed during the course of the illness

277 (19.0)

Patients with complete information about disease and therapy course.

363

 Last follow-up: alive1

23 (6.3)

 Study cohort: patients who died, i.e. patients with completed disease and therapy courses

340 (93.7)

Study cohort

340

 A. Breast cancer-related radiotherapy

165 (48.5)

 B. No radiotherapy

175 (51.5)

Breast cancer-related radiotherapy

 

Number of patients

165

Number of series

255

 median/mean (range)

1/1.6 (1-5)

Number of planning target volumes

337

 median/mean (range)

2/2.0 (1-8)

Metastatic sites and radiation volumes

337

 Breast and locoregional lymph nodes

35 (10.4)

  - primary tumor region after surgery (PMD)

8 (2.4)

  - primary breast tumor without surgery (PMD)

3 (0.9)

  - recurrence at the chest wall, no surgery

6 (1.8)

  - chest wall after surgery for local recurrence

1 (0.3)

  - recurrence at locoregional lymph nodes

17 (5.0)

 Bone

217 (64.4)

  - vertebrae and osseous pelvis

137 (40.7)

  - other sites

80 (23.7)

 Brain

57 (16.9)

 Other locations

28 (8.3)

  - skin/soft tissue

13 (3.8)

  - mediastinum

6 (1.8)

  - eye

3 (0.9)

  - lung

3 (0.9)

  - cervical lymph nodes

2 (0.6)

  - liver

1 (0.3)

  1. BBCD: Basel Breast Cancer Database; DM: distant metastases; PMD: primary metastatic disease; SMD: secondary metastatic disease.
  2. 1Last follow-up: January 2013. Three patients were alive with no evidence of disease. The long-time survival after pathologically confirmed distant metastatic disease of these three patients was as follows: i) 204 months after diagnosis of bone metastases, ii) 209 months after diagnosis of bone and lung metastases, iii) 230 months after diagnosis of lung metastases. Detailed description of these three cases in: [10].