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Table 2 Observational studies investigating the selenium levels in patients who underwent radiotherapy without selenium supplementation

From: Updates on clinical studies of selenium supplementation in radiotherapy

Study no. Reference Sample Measurement method Mean selenium levels (μg/l)
     Before radiotherapy During radiotherapy End of radiotherapy After completion of radiotherapy
1 Pothier et al. [17] Plasma AAS 61.8 (at stable stage) 1 week (n = 5) 34.3 - - -
2 Antila et al. [18] Serum AAS 130.7* Middle of therapy 124.4* 128.3* 2 weeks 126.7*
2 months 121.2*
3 Piccinini et al. [19] Plasma Fluorometric method Breast cancer: 71.81 - - - - -
Lung cancer:69.59
4 Rostkowska-Nadolska et al. [20] Serum AAS 253.8** - - - 6 weeks 267.5**
5 Yadav et al. [21] Serum AAS 62.7 - - 61.0 1 year Cured:91.5
Residual disease: 61.8
6 Last et al. [22] Serum ICP-MS 72.44* - - - - -
7 Fraunholz et al. [23] Whole blood AAS 75.64 - - 75.88 6 weeks 81.28
8 Franca et al. [24] Plasma AAS ≤60 years:101.8 - - ≤60 years: 58.1↓ - -
>60 years:65.2 >60 years: 33.7↓
9 Zeng YC et al. [25] Whole blood AAS 90.4 - - 56.3↓ - -’
10 Eroglu C et al. [26] Serum ICP-MS 58.09 - - 56.34 - -
12 Kiremidjian-Schumacher et al. [28] Plasma (placebo group) Graphite-furnace AAS 94.38 - - 8th weeks: 91.8 8 weeks 89.92
15 Muecke et al. [31] Whole blood (control group) AAS 63.2 50% of therapy 67.3 61.4 6 weeks 69
  1. ↓ = significant decrease.
  2. *1 μmol/l = 1 μg/l x 0.0127 [33].
  3. **1 ppm = 1,000 μg/l.