Significance of an increase in the Child-Pugh score after radiotherapy in patients with unresectable hepatocellular carcinoma

Table 4 Predictive factors that influence the overall mortality

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	p value	HR (95% CI)	p value
Gender (female)	1.329	0.262
Gender (female)	(0.807-2.192)	0.262
Age	1.002	0.826
Age	(0.982-1.023)	0.826
ECOG PS (1)	1.052	0.816
ECOG PS (1)	(0.686-1.613)	0.816
Hepatitis (B)	1.068	0.780
Hepatitis (B)	(0.672-1.697)	0.780
Liver cirrhosis (presence)	1.371	0.175
Liver cirrhosis (presence)	(0.868-2.164)	0.175
PVTT (presence)	1.457	0.079
PVTT (presence)	(0.957-2.217)	0.079
AFP (>400)	1.798	0.083
AFP (>400)	(0.926-3.484)	0.083
Pretreatment CP class (B)	1.834	0.038	1.524	0.255
Pretreatment CP class (B)	(1.033-3.257)	0.038	(0.738-3.144)	0.255
PTV (>225 cm³)	2.057	0.001	1.821	0.010
PTV (>225 cm³)	(1.355-3.125)	0.001	(1.157-2.865)	0.010
BED (>70 Gy)	0.839	0.448
BED (>70 Gy)	(0.532-1.322)	0.448
Hypofractionation (≧4 Gy per fraction)	0.731	0.146
Hypofractionation (≧4 Gy per fraction)	(0.479-1.116)	0.146
An increase in CP score after RT (≥2)	2.283	<0.001	1.795	0.015
	(1.494-3.484)		(1.121-2.881)

Abbreviations: HR hazard ratio, CI confidence interval, ECOG PS Eastern Cooperative Oncology Group performance status, PVTT portal vein tumor thrombosis, AFP alpha-fetoprotein, CP Child-Pugh, PTV planning target volume, BED biologically effective dose.

ISSN: 1748-717X