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Table 2 Details of recurrence patterns and salvage treatments

From: Initial and cumulative recurrence patterns of glioblastoma after temozolomide-based chemoradiotherapy and salvage treatment: a retrospective cohort study in a single institution

Patient no.

Patterns of recurrence

Salvage treatmentb

Current status

Initial

Cumulativea

Central

In-field

Marginal

Out-field

Distant

Surgery

SRT

Chemo

1

Distant

-

-

-

-

-

0

0

-

Dead

2

Central

3

0

1

0

2

Central (1)

Central(1)

ICE, BEV

Dead

Marginal (1)

3

Distant

-

-

-

-

-

0

0

ICE

Dead

4

Out-field

0

0

0

2

0

0

Out-field (2)

ICE, BEV, Others

Dead

5

Central

1

0

0

0

1

Central (2)

Central (1)

ICE

Dead

6

Central

1

0

0

0

0

Central (2)

0

ICE

Dead

7

Central

2

0

1

0

2

Central (2)

Central (1)

ICE, BEV, Others

Dead

8

Central

2

0

0

0

1

0

0

ICE, BEV

Dead

9

In-field

1

0

1

2

1

Central + In-field (1)

Marginal (1)

ICE, BEV

Dead

10

Central

0

1

0

1

1

Central (1)

0

ICE, BEV

Dead

11

Central

2

1

0

0

1

Central (1)

Central (2)

ICE, BEV, Others

Dead

In-field (1)

12

Out-field

0

0

0

2

1

0

Out-field (1)

ICE, BEV

Alive

13

Central

0

0

0

0

1

0

0

ICE

Dead

14

Central

2

0

0

0

1

Central (2)

Central (1)

ICE, BEV

Dead

15

In-field

-

-

-

-

-

0

In-field (1)

-

Alive

16

Central, In-field

1

1

0

0

1

Central (1)

Central +

ICE, BEV

Dead

In-field (1)

17

Central, Distant

-

-

-

-

-

0

0

-

Dead

18

Central

1

1

0

0

1

Central (1)

0

ICE

Dead

In-field (1)

19

Central

1

0

0

0

1

Central (2)

0

ICE

Dead

20

In-field

0

1

0

1

1

0

In-field (1)

ICE, Others

Alive

In-field + Out-field + Distant (1)

21

Central, Distant

-

-

-

-

-

0

0

-

Dead

  1. BEV: bevacizumab.
  2. ICE: ifosfamide, carboplatin, and etoposide.
  3. SRT: stereotactic radiotherapy.
  4. aCumulative recurrence patterns were classified and counted each time a new recurrent lesion was detected in follow-up MRI scans after the initial recurrence. Five patients had no scans after the initial recurrence and were excluded from the analysis of cumulative recurrence.
  5. bRegarding local salvage, recurrence patterns of treated lesions are described; repeat local salvage numbers are also indicated.