Intraoperative Electron Beam Radiotherapy (IOERT) in the management of locally advanced or recurrent cervical cancer

Table 4 Multivariate analysis of potential prognostic risk factors in patients treated with IOERT for recurrent cervical cancer

Variable	CC			LRC			CSS
Variable	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
High grade tumor	0.92	0.17-3.97	0.91	0.78	0.24-2.14	0.64	0.40	0.14-0.96	0.04
Recurrence ≤6 months after initial therapy	0.24	0.03-4.88	0.28	0.32	0.08-2.15	0.21	0.10	0.03-0.40	0.002
Previous RT	2.21	0.57-9.00	0.25	1.26	0.43-3.51	0.66	1.40	0.60-3.20	0.43
Pelvic exenteration	4.18	1.15-20.62	0.02	3.01	1.19-8.55	0.02	1.75	0.83-3.90	0.15
Surgical margin grade
R0 vs. R2	0.69	0.13-3.52	0.65	1.60	0.56-4.61	0.38	2.25	0.94-5.42	0.07
R1 vs. R2	0.54	0.12-1.90	0.35	1.20	0.47-2.89	0.69	2.02	0.92-4.34	0.08
R0 vs. R1	1.29	0.34-5.61	0.72	1.33	0.51-3.64	0.56	1.11	0.50-2.50	0.79
Perioperative RT	5.54	1.52-23.86	0.009	3.38	1.30-9.19	0.01	2.09	0.93-4.67	0.07
Perioperative systemic therapy	0.98	0.33-3.10	0.97	0.74	0.33-1.63	0.45	0.86	0.44-1.69	0.66

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