Intraoperative Electron Beam Radiotherapy (IOERT) in the management of locally advanced or recurrent cervical cancer

Table 3 Univariate analysis of potential prognostic risk factors in patients treated with IOERT for recurrent cervical cancer

Variable	3-year CC, %	P	3-year LRC, %	P	3-year FFDR, %	P	3-year CSS, %	P
Tumor grade		0.68		0.61		0.46		0.21
Low	92		50		71		59
High	65		47		42		25
Previous RT		0.22		0.61		0.08		0.28
Yes	71		54		50		33
No	66		46		37		26
Multiple previous recurrences		0.95		0.20		0.77		0.72
Yes	65		45		50		32
No	71		54		47		31
Time period of IOERT		0.16		0.13		0.63		0.45
1983-1996	60		40		45		27
1997-2010	81		68		50		39
Time from diagnosis to recurrence		0.76		0.47		0.13		0.001
≤6 months	80		60		25		0
>6 months	70		52		49		34
Tumor size		0.67		0.97		0.46		0.82
<3 cm	44		35		42		22
≥3 cm	74		55		48		34
Type of surgery		0.13		0.12		0.60		0.30
Exenteration	77		58		46		41
Less extensive resection	66		49		48		27
Surgical margin grade		0.17		0.13		0.004		0.04
R0	82		71		61		45
R1	55		36		45		27
R2	81		53		25		14
Pelvic sidewall involvement		0.77		0.76		0.89		0.37
Yes	69		50		46		28
No	70		55		48		39
Perioperative RT		0.13		0.11		0.34		0.29
Yes	76		60		44		36
No	52		33		60		22
Perioperative systemic therapy		0.35		0.97		0.44		0.81
Yes	74		54		53		31
No	66		51		43		32

Abbreviations: CC = central control; LRR = locoregional control; FFDR = freedom from distant recurrence; CSS = cause-specific survival; RT = radiotherapy; IOERT = intraoperative electron beam radiotherapy.

ISSN: 1748-717X