Feasibility and efficacy of chemoradiotherapy for elderly patients with locoregionally advanced nasopharyngeal carcinoma: results from a matched cohort analysis

Table 4 Patients experienced severe (grade 3 or 4) toxicities by treatment group

Toxicity	CRT (%, N=101)			RT (%, N=101)			P
	Grade 3	Grade 4	All	Grade 3	Grade 4	All
Acute toxicity
Leukopenia	12 (11.9)	0 (0)	12 (11.9)	0 (0)	0 (0)	0 (0)	< 0.001
Granulocytopenia	17 (16.8)	0 (0)	17 (16.8)	0 (0)	0 (0)	0 (0)	< 0.001
Thrombocytopenia	5 (5.0)	0 (0)	5 (5.0)	0 (0)	0 (0)	0 (0)	0.059
Anemia	6 (5.9)	0 (0)	6 (5.9)	1 (1.0)	0 (0)	1 (1.0)	0.118
Mucositis	52 (51.5)	1 (1.0)	53 (52.5)	38 (37.6)	0 (0)	38 (37.6)	0.034
Dermatitis	13 (12.9)	0 (0)	13 (12.9)	8 (7.9)	0 (0)	8 (7.9)	0.249
Hearing loss	1 (1.0)	0 (0)	1 (1.0)	0 (0)	0 (0)	0 (0)	1.000
Emesis	6 (6.0)	0 (0)	6 (6.0)	0 (0)	0 (0)	0 (0)	0.029
Hepatitis	2 (2.0)	0 (0)	2 (2.0)	2 (2.0)	0 (0)	2 (2.0)	1.000
Total any	65 (64.4)	1 (1.0)	66 (65.3)	44 (43.6)	0 (0)	44 (43.6)	0.002
Late toxicity
Xerostomia	2 (2.0)	0 (0)	2 (2.0)	2 (2.0)	0 (0)	2 (2.0)	1.000
Ear (deafness/otitis)	8 (8.0)	0 (0)	8 (8.0)	9 (8.9)	0 (0)	9 (8.9)	0.800
Subcutaneous Fibrosis	6 (6.0)	0 (0)	6 (6.0)	8 (7.9)	0 (0)	8 (7.9)	0.580
Trismus	3 (3.0)	0 (0)	3 (3.0)	1 (1.0)	0 (0)	1 (1.0)	0.621
Total any	11 (10.1)	0 (0)	11 (10.1)	13 (12.9)	0 (0)	13 (12.9)	0.664

ISSN: 1748-717X