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Table 1 Detailed patient overview

From: Hypofractionated carbon ion therapy delivered with scanned ion beams for patients with hepatocellular carcinoma – feasibility and clinical response

Patient no.

Gender

Age

Number of lesions

Number of irradiated lesions

Max. diameter [cm]

Pre-treatment in-loco

Histology

LC [months]

OS [months]

Response

Comorbidities

Comment

1

F

78

1

1

4.5

none

yes

9.4

10.7

PR

History of breast cancer and stroke, diabetes mell. type II

PROMETHEUS

2

M

63

1

1

2.0

Yes, RFA in loco

no, local relapse, CT + MRI

11.3

11.3

SD

History of metastasized seminoma, AL-amyloidosis type lambda, MALT-lymphoma of the lung, cardiomyopathy, coronary heart disease, diabetes mell. Type II

 

3

M

67

1

1

3.3

none

No, CT + MRI

11.8

12.7

PR

diabetes mell. type II, myasthenia gravis, congestive heart failure

 

4

F

78

2

2

3.7 and 0.9

none

Yes

11.9

11.9

PR

diabetes mell. type II, COPD II°

 

5

M

53

multiple

1

4.0

none

Yes

3.4

3.4

SD

History of renal cell carcinoma, cardiomyopathy, coronary heart disease, diabetes mell. type II

Sorafenib and liver transplantation after RT

6

F

71

2

1

3.4

Yes, PEI and TACE

no, local relapse, CT + MRI

2.7

4.0*

SD

diabetes mell. type II, history of pituitary adenoma, hemochromatosis

Received TACE for 2nd lesion, PROMETHEUS

  1. F = female, M = male, CT = computed tomography, MRI = magnetic resonance imaging, LC = local control, OS = overall survival, PR = partial remission, SD = stable disease, RT = radiotherapy, PEI = percutaneous ethanol instillation, TACE = trans-arterial chemo-embolization, RFA = radiofrequency ablation, * deceased, PROMETHEUS = included in the running clinical trial, COPD = chronic obstructive pulmonary disease.