Phase I study of hypofractionated intensity modulated radiation therapy with concurrent and adjuvant temozolomide in patients with glioblastoma multiforme

Table 6 Univariate and multivariate analysis of prognostic factors for OS

	Univariate			Multivariate
Variable	HR	95% CI	P	HR	95% CI	P
KPS
≥ 80 vs. 70	1.32	0.50-3.46	0.573			NS
RPA class
Class III vs. Class IV and V	2.51	0.56-11.20	0.228			NS
Adjuvant TMZ
≥3 cycles vs. < 3 cycles	0.79	0.64-0.97	0.024	0.83	0.69-0.99	0.042
Extent of resection
GTR vs. biopsy or STR	1.99	0.45-8.86	0.368			NS
Time interval between the date of surgery and start of RT
≥ 6 weeks vs. < 6 weeks	3.18	1.20-8.40	0.02	2.94	1.06-8.18	0.039

Abbreviations: OS: overall survival; HR: hazard ration; CI: confidence interval; KPS: Karnofsky performance status; RPA: recursive partitioning analysis; TMZ: Temozolomide; GTR: gross total resection; STR: subtotal resection; RT: radiation therapy.

ISSN: 1748-717X