|
Perh Lind et al. 1994– 1998 [17]
|
Sweden
|
475
|
Clinical RP CTC-NCIC
|
Ipsilateral V20Gy: ≈7%,≈20%, ≈30%,≈35%
|
2 sided Gamma statistics, G = 0.638
|
<0.001
|
Correlation between increasing V20Gy to grade of lung toxicity. Assessed at 1,4 and 7 months.
|
|
Zsusana Kahan et al. 2001– 2004 [31]
|
Hungary
|
119
|
Radiological RP – CTC 2.0
|
Mean Ipsilateral V20Gy (%) (RP- vs RP+)
|
Student’s t-test (24.8% vs 31.1%)
|
0.005
|
3 and 12 months post RT CT-Thorax.
|
|
Javier Jaen et al. 2002 [44]
|
Spain
|
39
|
Change in perfused volume(%)
|
Bilateral V20Gy
|
Corr. Coefficient r = −0.414
|
0.026
|
6,12 and 36 months lung perfusion test.
|
|
Marco Krengli et al. 2002 – 2003 [23]
|
Italy
|
41
|
Radiological RP (G0-3)
|
Ipsi V25Gy
|
ANOVA
|
0.0007(G2 vs G0)
|
3 and 9 months post RT CT-Thorax.
|
|
0.02 (G3 vs G0)
|
|
Ulla Goldman et al. 2003 – 2005 [22]
|
Sweden
|
40
|
Radiological RP – Arigada score
|
Mean Ipsilateral V20Gy (%) (RP- vs RP+)
|
24% vs 30%
|
-
|
4 months (CT-Thorax) and 5 months (CXR).
|
|
Akiko Kubo et al. 2005 – 2007 [24]
|
Japan
|
413
|
Radiological RP – CTC/AE 3.0
|
Ipsi V20Gy ≤ 9.7%, Ipsi V20Gy ≥ 9.8%
|
Cox regression RR = 0.67
|
0.13 (NS)
|
3 monthly CXR for 1 year. Only tangential whole breast irradiation.
|
