Table 1 Relationship between dose volume parameters and early lung toxicity in 3D-CRT for BC in world literature

Perh Lind et al. 1994– 1998 [17]

Sweden

475

Clinical RP CTC-NCIC

Ipsilateral V_20Gy: ≈7%,≈20%, ≈30%,≈35%

2 sided Gamma statistics, G = 0.638

<0.001

Correlation between increasing V_20Gy to grade of lung toxicity. Assessed at 1,4 and 7 months.

Zsusana Kahan et al. 2001– 2004 [31]

Hungary

119

Radiological RP – CTC 2.0

Mean Ipsilateral V_20Gy (%) (RP- vs RP+)

Student’s t-test (24.8% vs 31.1%)

0.005

3 and 12 months post RT CT-Thorax.

Javier Jaen et al. 2002 [44]

Spain

39

Change in perfused volume(%)

Bilateral V_20Gy

Corr. Coefficient r = −0.414

0.026

6,12 and 36 months lung perfusion test.

Marco Krengli et al. 2002 – 2003 [23]

Italy

41

Radiological RP (G0-3)

Ipsi V_25Gy

ANOVA

0.0007(G2 vs G0)

3 and 9 months post RT CT-Thorax.

0.02 (G3 vs G0)

Ulla Goldman et al. 2003 – 2005 [22]

Sweden

40

Radiological RP – Arigada score

Mean Ipsilateral V_20Gy (%) (RP- vs RP+)

24% vs 30%

-

4 months (CT-Thorax) and 5 months (CXR).

Akiko Kubo et al. 2005 – 2007 [24]

Japan

413

Radiological RP – CTC/AE 3.0

Ipsi V_20Gy ≤ 9.7%, Ipsi V_20Gy ≥ 9.8%

Cox regression RR = 0.67

0.13 (NS)

3 monthly CXR for 1 year. Only tangential whole breast irradiation.