Skip to main content

Table 1 Relationship between dose volume parameters and early lung toxicity in 3D-CRT for BC in world literature

From: Meta-analysis of incidence of early lung toxicity in 3-dimensional conformal irradiation of breast carcinomas

Author, Year of data collection Country n RP endpoint Prognostic groups Test type p value Comments
Perh Lind et al. 1994 1998 [17] Sweden 475 Clinical RP CTC-NCIC Ipsilateral V20Gy: ≈7%,≈20%, ≈30%,≈35% 2 sided Gamma statistics, G = 0.638 <0.001 Correlation between increasing V20Gy to grade of lung toxicity. Assessed at 1,4 and 7 months.
Zsusana Kahan et al. 2001 2004 [31] Hungary 119 Radiological RP – CTC 2.0 Mean Ipsilateral V20Gy (%) (RP- vs RP+) Student’s t-test (24.8% vs 31.1%) 0.005 3 and 12 months post RT CT-Thorax.
Javier Jaen et al. 2002 [44] Spain 39 Change in perfused volume(%) Bilateral V20Gy Corr. Coefficient r = −0.414 0.026 6,12 and 36 months lung perfusion test.
Marco Krengli et al. 2002 – 2003 [23] Italy 41 Radiological RP (G0-3) Ipsi V25Gy ANOVA 0.0007(G2 vs G0) 3 and 9 months post RT CT-Thorax.
0.02 (G3 vs G0)
Ulla Goldman et al. 2003 – 2005 [22] Sweden 40 Radiological RP – Arigada score Mean Ipsilateral V20Gy (%) (RP- vs RP+) 24% vs 30% - 4 months (CT-Thorax) and 5 months (CXR).
Akiko Kubo et al. 2005 – 2007 [24] Japan 413 Radiological RP – CTC/AE 3.0 Ipsi V20Gy ≤ 9.7%, Ipsi V20Gy ≥ 9.8% Cox regression RR = 0.67 0.13 (NS) 3 monthly CXR for 1 year. Only tangential whole breast irradiation.
  1. RP radiation pneumonitis, n number of patients, Vdose, volume of lung (%) receiving a certain dose (Gray), CI confidence interval, CTC / CTC-NCIC common toxicity criteria, RT radiotherapy.