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Table 1 Patient characteristic

From: Adjuvant radiotherapy of regional lymph nodes in breast cancer - a meta-analysis of randomized trials

  MA.20[16] EORTC[17] French[15]
Recruitment years 2000-2007 1996-2004 1991-1997
Number of patients 1832 4004 1334
Median age 54 54 57
Node positive 85% 56% 75%
Breast surgery 100% breast conserving 75% breast conserving 100% mastectomy
CHX 91% 85% 61%
ER/PR negative 25% 16% 7%
Unknown ER/PR status n.a. 6% 40%
Main inclusion criteria N + or high risk* N0 any location N + or medial/central tumor N + or medial/central tumor
Breast/chest wall Both arms: 50 Gy / 25 fx Both arms 50 Gy / 25 fx Both arms according to practice of the center
Medial supraclavicular nodes Experimental arm: 45 Gy / 25 fx 50 Gy / 25 fx All patients: dose and fractionation according to practice of the center
Internal mammary nodes Experimental arm: 45 Gy / 25 fx Experimental arm: 50 Gy / 25 fx Experimental arm: 45 Gy / 20 fx
  1. *= > = 5 cm tumor, > = 2 cm tumor, and <10 axillary nodes removed with ER-, G3, or lymph vacular invation; n.a. = not available; fx = fractions; ER = estrogene receptor; PR = progesterone receptor.