Table 1 Patient characteristic
MA.20[16] | EORTC[17] | French[15] | |
|---|---|---|---|
Recruitment years | 2000-2007 | 1996-2004 | 1991-1997 |
Number of patients | 1832 | 4004 | 1334 |
Median age | 54 | 54 | 57 |
Node positive | 85% | 56% | 75% |
Breast surgery | 100% breast conserving | 75% breast conserving | 100% mastectomy |
CHX | 91% | 85% | 61% |
ER/PR negative | 25% | 16% | 7% |
Unknown ER/PR status | n.a. | 6% | 40% |
Main inclusion criteria | N + or high risk* N0 any location | N + or medial/central tumor | N + or medial/central tumor |
Breast/chest wall | Both arms: 50 Gy / 25 fx | Both arms 50 Gy / 25 fx | Both arms according to practice of the center |
Medial supraclavicular nodes | Experimental arm: 45 Gy / 25 fx | 50 Gy / 25 fx | All patients: dose and fractionation according to practice of the center |
Internal mammary nodes | Experimental arm: 45 Gy / 25 fx | Experimental arm: 50 Gy / 25 fx | Experimental arm: 45 Gy / 20 fx |