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Table 3 Published studies of RFA and high-dose SBRT group of the present study

From: High-dose stereotactic body radiotherapy correlates increased local control and overall survival in patients with inoperable hepatocellular carcinoma

Study, year

Treatment

Study type

Number

Tumor size (cm)

Local control (%)

Overall survival (%)

Severe toxicity (%)

Shiina 2005 (7)

RFA

RCT

118

Median 2.2

98

74 (4-year)

5.1

Bouza 2009 (8)

RFA

Meta-analysis

396

Mean 2.6

93

62 (4-year)

4.1

Waki 2010 (38)

RFA

Retrospective

88

Median 1.8

95

70 (5-year)

5.7

Feng 2012 (39)

RFA

RCT

84

Mean 2.4

96

67 (3-year)

9.5

Shiina 2012 (6)

RFA

Retrospective

1170

Median 2.0 Mean 2.5

97

60 (5-year)

2.2

Present study(> 54 Gy)

SBRT

Retrospective

32 (Rec 53%)

Median 3.0 Mean 3.1

100

68 (4.5-year)

Bowel 3.1; Others 3.1

  1. Abbreviations: SBRT stereotactic body radiotherapy, RFA radiofrequency ablation, RCT randomized controlled trial, Rec, recurrence.
  2. Comparison between recent data concerning published RFA for hepatocellular carcinoma and high-dose (> 54 Gy) SBRT group of the present study. In these RFA series, all patients had initial disease and received RFA as the first treatment.