Three-dimensional conformal radiotherapy with concurrent chemotherapy for postoperative recurrence of esophageal squamous cell carcinoma: clinical efficacy and failure pattern

Table 2 Univariate analysis of prognostic factors of overall survival (n = 83)

Variable	HR, 95% CI	p value
Sex (male vs. female)	0.70 (0.26-1.89)	0.477
Age (>55 yrs vs. ≤55 yrs)	0.67 (0.28-1.57)	0.344
ECOG performance status (0–1 vs. 2–3)	0.72 (0.27-1.86)	0.523
Primary tumor location (Upper vs. Middle vs. Lower)	0.80 (0.40-1.61)	0.533
Radical surgery (Two-field vs. three-field)	1.31 (0.55-3.12)	0.540
Histology of primary tumor (G1-2 vs. G3-4)	1.05 (0.51-2.13)	0.905
Stage of primary tumor (I-II stage vs. III stage)	1.66 (0.88-3.12)	0.120
Time between surgery and RT (>14 mon vs. ≤14 mon)	0.77 (0.34-1.77)	0.538
Recurrence site (AR vs. LR)	2.70 (1.06-6.88)	*0.028* ^*
RT dose(>60 Gy vs. ≤60 Gy)	1.26 (0.47-3.35)	0.648
Concurrent chemotherapy (PF vs. TP)	0.58 (0.31-1.09)	*0.090* ^#
Tumor response after CCRT (CR vs. non-CR)	4.20 (2.04-8.65)	*0.000* ^*

Note: *Univariate analysis showed that tumor response after CCRTand recurrence site had significant associations with OS. # Univariate analysis showed that concurrent chemotherapy showed a trend of association with OS.

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