Table 2 Survey of clinical outcomes after re-irradiation: fractionated stereotactic radiation therapy (FSRT), radiosurgery (SRS), brachytherapy (BT) of recurrent GBM
Authors | Patients (n) | Type of RT | Total dose/fractions | Outcomes from the re-irradiation |
|---|---|---|---|---|
Cho et al.[30] | 25 | FSRT | Median dose of 37.5 Gy (range, 20-45 Gy) /2.5 Gy fractions (range, 1.8-3 Gy) | Median survival 12 months |
Cho et al.[30] | 46 | SRS | Median total dose of 17 Gy delivered to the median of 50% isodose surface | Median survival 11 months |
Combs et al.[31] | 59 | FSRT | 36 Gy/2 Gy fractions | Median OS 8 months |
1-year survival rates 23% | ||||
Median PFS 5 months | ||||
1-year PFS 5% | ||||
Vordermark et al.[33] | 19 | FSRT | Median total dose 30 Gy (range, 20–30 Gy) /5 Gy fractions (range, 4–10 Gy) | Median OS 7.9 months |
Simon et al.[49] | 42 | Iridium BT | 50 Gy | Median OS 12.5 months |
Chan et al.[50] | 24 | BT | 53 Gy | Median OS 9.1 months |
Larson et al.[51] | 14 | SRS | 15 Gy/1 fraction | Median OS 9.5 months |
Combs et al.[32] | 32 | SRS | 15 Gy/1 fraction | Median OS 10 months |
Shrieve et al.[52] | 86 | SRS | 13 Gy/1 fraction | Median OS 10.2 months |
Shrieve et al.[52] | 32 | BT | 50 Gy | Median OS 11.5 months |
Grosu et al.[53] | 33 | FSRT | 30 Gy | Median OS 8 months (for astrocytomas and gliomas) |
Kohshi et al.[54] | 25 | FSRT | 22 Gy | Median OS 11 months |
Ernst-Stecken et al.[55] | 15 | FSRT | 35 Gy/7 Gy fractions | 6 months PFS 75% |
12 months PFS 53% | ||||
Fokas et al.[56] | 53 | FSRT | Median dose 30 Gy (range 20-60 Gy)/ 3 Gy fractions (range 2-5 Gy) | Median OS 9 months |
1-year PFS 22% | ||||
2-year PFS 5% | ||||
Henke et al.[57] | 31 (2 grade III, 29 grade IV) | FSRT | Median total dose 20Gy (range, 20–25)/ 5 Gy fractions | Median OS 10.2 months, |
Fogh et al.[58] | 147 (42 grade III, 105 grade IV) | FSRT | Median dose 35 Gy in 3.5-Gy fractions | Median OS 11 months for grade III and 8 months for grade IV |
Shepherd et al.[59] | 29 | FSRT | Median dose 35 Gy (range, 20–50 Gy)/ 5 Gy fractions | Median OS 10.7 months |
Glass et al.[60] | 20 (7 grade III, 13 grade IV) | FSRT | Median dose 38 Gy (range, 35–42 Gy)/ 3.5–6 Gy fractions | Median OS 12.7 months |
Hudes et al. [61] | 19 | FSRT | Median dose 30 Gy (range, 24–35 Gy)/ 3–3.5 Gy fractions | Median OS 10.5 months |
Lederman et al.[34] | 88 | FSRT | Total dose 18–36/ 4–9 Gy (weekly) | Median OS 7 months |
Voynov et al.[62] | 10 (5 WHO grade III, 5 grade IV) | FSRT | 30 Gy /5 Gy fractions | Median OS 10.1 months |