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Table 4 Clinical, functional, and dosimetric factors on RP

From: Variations of circulating endothelial progenitor cells and transforming growth factor-beta-1 (TGF-β1) during thoracic radiotherapy are predictive for radiation pneumonitis

Characteristics

RP

No-RP

P

Age Mean (range)

58.5 (38–70)

59 (40–70)

0.83

Gender (Male/Female)

25/13

23/19

0.36

KPS Mean (range)

90.5 (80–100)

91.9 (80–100)

0.40

AJCC clinical stage (IIIA/ IIIB)

18/20

17/25

0.53

Histology (AD/SQ/LA/OT)

17/20/1/0

14/23/2/3

0.30

Tumor site (UM/LO)

29/9

28/14

0.34

Comorbidity (COPD/CA/DI)

2/1/0

5/2/1

0.80

Smoking history (NO/CU)

20/18

14/28

0.81

Chemotherapy (Yes/ No)

30/8

26/16

0.10

V20 Mean (range)

38.2 (8.6-63.3)

29.6 (8.9-60.2)

0.02

V30 Mean (range)

33.9 (7.9-48.5)

25.6 (6.6-51.0)

0.001

DLCO (%) Mean (range)

87.4 (61.3-99.4)

85.7 (65.4-98.7)

0.53

FEV1 (%) Mean (range)

86.3 (63.6-99.0)

83.4 (66.6-99.4)

0.24

FVC (%) Mean (range)

90.9 (75.6-99.6)

89.5 (74.3-99.4)

0.38

MLD Mean (range)

16.7 (5.9-25.6)

14.0 (7.9-21.3)

0.008

Weight loss ≥ 5% (Yes/ No)

18/20

11/31

0.0

  1. Abbreviations: KPS: Karnofsky performance status, AD: Adenocarcinoma, SQ: Squamous cell, LA: Large cell carcinoma, OT: Other, UM: Upper&middle, LO: Lower, COPD: chronic obstructive pulmonary disease, CA: Cardiovascular disease, DI: diabetes, NO: Nonsmoker, CU: Current or ex smoker, V20: Percentage of irradiated lung volume exceeding 20 Gy, V30: Percentage of irradiated lung volume exceeding 30 Gy, DLCO: Diffusion capacity for carbon monoxide, FEV1: Forced expiratory volume at 1 second, FVC: Forced vital capacity, MLD: mean lung dose.