Table 4 Results of reirradiation studies in summary
From: The benefit of whole brain reirradiation in patients with multiple brain metastases
Sadikov[9] | Hazuka[10] | Cooper[11] | Wong[12] | Son[13] | Our study | |
|---|---|---|---|---|---|---|
n = 72 | n = 44 | n = 52 | n = 86 | n = 17 | n = 28 | |
WBRT | ||||||
First course | 20 Gy/5 fr | 30 Gy/10 fr | 30 Gy/10 fr | 30 Gy/10 fr | 35 Gy/14 fr | 30 Gy/10 fr |
Second course | 25 Gy/10 fr | 25 Gy/8 fr | 25 Gy/10 fr | 20 Gy/10 fr | 21.6 Gy/12 fr | 25 Gy/10 fr |
Interval (median) | 9.6 months | 7.8 months | >4 months (mean) | 7.6 months | 15 months | 9.5 months |
Other treatments to the brain | SRS in 9 patients | SRS in 10 patients | ||||
Surgery in 4 patients | ||||||
Response (%) | 40 | 27 | 42 | 70 | 80 | 39 |
Survival after reirradiation (median) | 4.1 months | 2 months | 4 months | 4 months | 5.2 months | 3 months |
10 months (responders) | ||||||
3 months (nonresponders) |