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Table 2 Summary of NTCP modeling studies of lung toxicity

From: Clinical implications in the use of the PBC algorithm versus the AAA by comparison of different NTCP models/parameters

Organ: Lung; End-point: Pneumonitis

Ref.

LKB model parameters

Notes

 

n

D50(Gy)

m

 

Emami et al. [39] / Burman et al. [23]†

0.87

24.50

0.18

 

Kwa et al. [60]

1.00

30.50

0.30

 

Seppenwoolde et al. [38]

0.99

30.80

0.37

 

De Jeager et al. [24]*

1.00

34.10

0.45

 

De Jeager et al. [24]**

1.00

29.20

0.45

 

Ref.

Seriality model parameters

Notes

 

γ

D 50 (Gy)

s

 

Emami et al. [39] / Ågren-Cronqvist [40]‡

2.10

24.50

0.0061

 

Seppenwoolde et al. [38]

0.900

34.00

0.060

 

Gagliardi et al. [61]

0.966

30.10

0.012

lungs were considered as separate organs

  1. †Clinical data from Emami et al. [39], model fitting by Burman et al. [23].
  2. * Tissue inhomogeneity correction: Equivalent-path.
  3. ** Tissue inhomogeneity correction: Convolution-superposition.
  4. ‡Clinical data from Emami et al. [39], model fitting by Ågren-Cronqvist [40].