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Table 2 Factors for predicting the response of portal vein tumor thrombosis

From: Hypofractionated radiotheapy using helical tomotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis

Factors   Responder Non-responder P-value
   CR + PR (n = 15) SD + PD (n = 20)  
Age (yrs) ≤60 7 14 0.163
  >60 8 6  
Gender Male 12 16 1.000
  Female 3 4  
ECOG 1 8 10 0.845
  2 7 10  
Etiology Viral 13 17 0.889
  Non-viral 2 3  
Child-Pugh classification A 15 13 0.010
  B 0 7  
JIS score 2 14 12 0.026
  3 1 8  
Pretreatment AFP (ng/ml) ≤ 20 5 5 0.589
  > 20 10 15  
Type of HCC Nodular 10 10 0.324
  Diffuse infiltrative 5 10  
Multiplicity Solitary 8 16 0.093
  Multiple 7 4  
Location of thrombi PV branch 9 8 0.241
  Main portal trunk 6 12  
BED (Gy10, mean ± SD)   70.0 ± 6.5 68.1 ± 11.0 0.530
  1. Abbreviations: CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; ECOG, Eastern Cooperative Oncology Group; JIS, Japan integrated staging; AFP, α-fetoprotein; HCC, Hepatocellular carcinoma; PV, Portal vein; BED, biologically effective dose; SD, standard deviation.
  2. P-values are obtained by chi-square test, Fisher’s exact test, or t-test.