Table 3 Results of automated quantification of SNP variables before and after brachytherapy (all normalised to an area of 1 mm 2 )
Corneal zone | Before brachytherapy | 3 days after brachytherapy | 1 month after brachytherapy | 4 months after brachytherapy | 7 months after brachytherapy | |
|---|---|---|---|---|---|---|
Component pixels (n) | Applicator | 45050.0 ± 23273.0 | 2031.3 ± 2637.8 | 11714.1 ± 12851.5 | 14118.8 ± 7941.5 | 38592.5 ± 25383.8 |
Central | 42589.6 ± 16506.1 | 1552.1 ± 2688.3 | 15663.8 ± 15369.3 | 14048.4 ± 7681.3 | 30116.7 ± 18365.5 | |
Distal | 41421.3 ± 6598.9 | 11056.3 ± 6637.8 | 21918.8 ± 21252.3 | 30116.7 ± 24992.7 | 37814.6 ± 18680.4 | |
Total number of nerve fibre components (n) | Applicator | 50.0 ± 34.7 | 4.2 ± 3.6 | 23.4 ± 16.4 | 31.3 ± 22.8 | 53.8 ± 26.0 |
Central | 52.1 ± 25.5 | 2.1 ± 3.6 | 15.0 ± 13.0 | 12.5 ± 5.1 | 66.7 ± 36.1 | |
Distal | 50.0 ± 40.3 | 25.0 ± 22.5 | 14.1 ± 16.4 | 22.9 ± 7.2 | 70.8 ± 18.0 | |
Skeleton pixels (n) | Applicator | 13715.6 ± 7004.1 | 622.9 ± 809.2 | 3456.3 ± 3774.2 | 4300.0 ± 2411.0 | 11622.5 ± 7566.4 |
Central | 12876.0 ± 5053.8 | 460.4 ± 797.5 | 4627.5 ± 4483.7 | 4217.2 ± 2308.7 | 9110.4 ± 5497.3 | |
Distal | 12722.5 ± 1979.2 | 3347.9 ± 2056.2 | 6585.9 ± 6253.7 | 9077.1 ± 7387.1 | 11422.9 ± 5671.4 | |
Single nerve fibres (n) | Applicator | 240.6 ± 184.0 | 4.2 ± 3.6 | 37.5 ± 39.9 | 40.6 ± 25.8 | 188.8 ± 133.4 |
Central | 235.4 ± 167.5 | 6.3 ± 10.8 | 51.3 ± 68.4 | 96.9 ± 112.9 | 116.7 ± 85.1 | |
Distal | 162.5 ± 84.7 | 47.9 ± 28.2 | 126.6 ± 127.5 | 175.0 ± 197.3 | 189.6 ± 108.7 | |
Average single fibre length (μm) | Applicator | 83.4 ± 34.3 | 166.4 ± 154.1 | 101.1 ± 52.4 | 147.3 ± 77.4 | 74.2 ± 13.5 |
Central | 74.4 ± 31.2 | 84.3 ± 0 | 151.9 ± 65.7 | 83.8 ± 46.1 | 89.2 ± 19.4 | |
Distal | 100.2 ± 37.8 | 93.5 ± 60.7 | 61.1 ± 7.9 | 74.4 ± 22 | 68.8 ± 7.2 | |
Nerve fibre density (mm/mm2) | Applicator | 15.142 ± 7.93 | 0.693 ± 0.908 | 3.896 ± 4.315 | 4.713 ± 2.638 | 12.945 ± 8.586 |
Central | 14.207 ± 5.553 | 0.527 ± 0.913 | 5.322 ± 5.205 | 4.736 ± 2.538 | 10.031 ± 6.221 | |
Distal | 13.827 ± 2.279 | 3.725 ± 2.302 | 7.471 ± 7.278 | 10.151 ± 8.627 | 12.643 ± 6.348 | |
Connectivity points (n) | Applicator | 14.2 ± 10.4 | 0 ± 0 | 1.3 ± 2.5 | 5.6 ± 6.6 | 13 ± 11.5 |
Central | 14.2 ± 6.5 | 0 ± 0 | 2.0 ± 3.3 | 1.3 ± 2.5 | 13.3 ± 10.4 | |
Distal | 13.0 ± 9.6 | 1.7 ± 1.4 | 5.6 ± 6.6 | 8.3 ± 8.8 | 12.5 ± 9.0 | |
Branches (n) | Applicator | 104.2 ± 91.8 | 0 ± 0 | 7.8 ± 15.6 | 4.7 ± 6.0 | 73.8 ± 64.1 |
Central | 101.0 ± 101.6 | 2.1 ± 3.6 | 18.8 ± 35.1 | 45.3 ± 59.2 | 25.0 ± 33.1 | |
Distal | 61.3 ± 43.6 | 12.5 ± 16.5 | 62.5 ± 61.0 | 87.5 ± 120.5 | 58.3 ± 54.6 |