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Table 3 Results of automated quantification of SNP variables before and after brachytherapy (all normalised to an area of 1 mm 2 )

From: Changes in the micromorphology of the corneal subbasal nerve plexus in patients after plaque brachytherapy

  Corneal zone Before brachytherapy 3 days after brachytherapy 1 month after brachytherapy 4 months after brachytherapy 7 months after brachytherapy
Component pixels (n) Applicator 45050.0 ± 23273.0 2031.3 ± 2637.8 11714.1 ± 12851.5 14118.8 ± 7941.5 38592.5 ± 25383.8
  Central 42589.6 ± 16506.1 1552.1 ± 2688.3 15663.8 ± 15369.3 14048.4 ± 7681.3 30116.7 ± 18365.5
  Distal 41421.3 ± 6598.9 11056.3 ± 6637.8 21918.8 ± 21252.3 30116.7 ± 24992.7 37814.6 ± 18680.4
Total number of nerve fibre components (n) Applicator 50.0 ± 34.7 4.2 ± 3.6 23.4 ± 16.4 31.3 ± 22.8 53.8 ± 26.0
  Central 52.1 ± 25.5 2.1 ± 3.6 15.0 ± 13.0 12.5 ± 5.1 66.7 ± 36.1
  Distal 50.0 ± 40.3 25.0 ± 22.5 14.1 ± 16.4 22.9 ± 7.2 70.8 ± 18.0
Skeleton pixels (n) Applicator 13715.6 ± 7004.1 622.9 ± 809.2 3456.3 ± 3774.2 4300.0 ± 2411.0 11622.5 ± 7566.4
  Central 12876.0 ± 5053.8 460.4 ± 797.5 4627.5 ± 4483.7 4217.2 ± 2308.7 9110.4 ± 5497.3
  Distal 12722.5 ± 1979.2 3347.9 ± 2056.2 6585.9 ± 6253.7 9077.1 ± 7387.1 11422.9 ± 5671.4
Single nerve fibres (n) Applicator 240.6 ± 184.0 4.2 ± 3.6 37.5 ± 39.9 40.6 ± 25.8 188.8 ± 133.4
  Central 235.4 ± 167.5 6.3 ± 10.8 51.3 ± 68.4 96.9 ± 112.9 116.7 ± 85.1
  Distal 162.5 ± 84.7 47.9 ± 28.2 126.6 ± 127.5 175.0 ± 197.3 189.6 ± 108.7
Average single fibre length (μm) Applicator 83.4 ± 34.3 166.4 ± 154.1 101.1 ± 52.4 147.3 ± 77.4 74.2 ± 13.5
  Central 74.4 ± 31.2 84.3 ± 0 151.9 ± 65.7 83.8 ± 46.1 89.2 ± 19.4
  Distal 100.2 ± 37.8 93.5 ± 60.7 61.1 ± 7.9 74.4 ± 22 68.8 ± 7.2
Nerve fibre density (mm/mm2) Applicator 15.142 ± 7.93 0.693 ± 0.908 3.896 ± 4.315 4.713 ± 2.638 12.945 ± 8.586
  Central 14.207 ± 5.553 0.527 ± 0.913 5.322 ± 5.205 4.736 ± 2.538 10.031 ± 6.221
  Distal 13.827 ± 2.279 3.725 ± 2.302 7.471 ± 7.278 10.151 ± 8.627 12.643 ± 6.348
Connectivity points (n) Applicator 14.2 ± 10.4 0 ± 0 1.3 ± 2.5 5.6 ± 6.6 13 ± 11.5
  Central 14.2 ± 6.5 0 ± 0 2.0 ± 3.3 1.3 ± 2.5 13.3 ± 10.4
  Distal 13.0 ± 9.6 1.7 ± 1.4 5.6 ± 6.6 8.3 ± 8.8 12.5 ± 9.0
Branches (n) Applicator 104.2 ± 91.8 0 ± 0 7.8 ± 15.6 4.7 ± 6.0 73.8 ± 64.1
  Central 101.0 ± 101.6 2.1 ± 3.6 18.8 ± 35.1 45.3 ± 59.2 25.0 ± 33.1
  Distal 61.3 ± 43.6 12.5 ± 16.5 62.5 ± 61.0 87.5 ± 120.5 58.3 ± 54.6