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Table 2 Patterns of failure according to CRT timing

From: Patterns of failure in patients with locally advanced rectal cancer receiving pre-operative or post-operative chemoradiotherapy

Site of failure   Pre-op CRT, n(%) Post-op CRT, n(%) P
Type of recurrence LR alone 17 (13.4) 8 (8.1) 0.573
  LR with DM 21 (16.5) 15 (15.2)  
  DM alone 89 (70.1) 76 (76.8)  
  Total 127 (100) 99 (100)  
DM site* Lung 64 (48.1) 44 (37.9) 0.208
  Liver 24 (18.0) 30 (25.9)  
  PAN 27 (20.3) 20 (17.2)  
  Others 18 (13.5) 22 (19.0)  
  Total 133 (100) 116 (100)  
Time to failure   Pre-op CRT, months Post-op CRT, months P
Type of recurrence LR alone 37.2 ± 21.2 35.2 ± 27.4 0.841
  LR with DM 25.6 ± 21.3 19.9 ± 13.3 0.372
  DM alone 21.2 ± 15.9 19.1 ± 12.1 0.334
  Total 24.1 ± 18.3 20.5 ± 14.5 0.112
DM site* Lung 24.3 ± 18.2 20.1 ± 10.7 0.130
  Liver 16.5 ± 9.3 18.2 ± 14.1 0.597
  PAN 18.8 ± 16.6 19.0 ± 13.5 0.964
  Others 21.5 ± 15.4 18.3 ± 13.9 0.494
  1. Abbreviations: CRT = chemoradiotherapy; LR = local recurrence; DM = distant metastasis; PAN = para-aortic lymph node.
  2. *Some patients had distant metastases occurring at multiple sites.
  3. Peritoneal seeding, inguinal lymph node, bone, brain, supraclavicular lymph node.
  4. Linear-by-linear association or t- test.