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Table 2 Patterns of failure according to CRT timing

From: Patterns of failure in patients with locally advanced rectal cancer receiving pre-operative or post-operative chemoradiotherapy

Site of failure

 

Pre-op CRT, n(%)

Post-op CRT, n(%)

P

Type of recurrence

LR alone

17 (13.4)

8 (8.1)

0.573

 

LR with DM

21 (16.5)

15 (15.2)

 
 

DM alone

89 (70.1)

76 (76.8)

 
 

Total

127 (100)

99 (100)

 

DM site*

Lung

64 (48.1)

44 (37.9)

0.208

 

Liver

24 (18.0)

30 (25.9)

 
 

PAN

27 (20.3)

20 (17.2)

 
 

Others

18 (13.5)

22 (19.0)

 
 

Total

133 (100)

116 (100)

 

Time to failure

 

Pre-op CRT, months

Post-op CRT, months

P

Type of recurrence

LR alone

37.2 ± 21.2

35.2 ± 27.4

0.841

 

LR with DM

25.6 ± 21.3

19.9 ± 13.3

0.372

 

DM alone

21.2 ± 15.9

19.1 ± 12.1

0.334

 

Total

24.1 ± 18.3

20.5 ± 14.5

0.112

DM site*

Lung

24.3 ± 18.2

20.1 ± 10.7

0.130

 

Liver

16.5 ± 9.3

18.2 ± 14.1

0.597

 

PAN

18.8 ± 16.6

19.0 ± 13.5

0.964

 

Others

21.5 ± 15.4

18.3 ± 13.9

0.494

  1. Abbreviations: CRT = chemoradiotherapy; LR = local recurrence; DM = distant metastasis; PAN = para-aortic lymph node.
  2. *Some patients had distant metastases occurring at multiple sites.
  3. Peritoneal seeding, inguinal lymph node, bone, brain, supraclavicular lymph node.
  4. Linear-by-linear association or t- test.