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Table 1 Planning and treatment parameters

From: Multi-institutional comparison of treatment planning using stereotactic ablative body radiotherapy for hepatocellular carcinoma – benchmark for a prospective multi-institutional study

 

A

B

C

D

TPS

XiO

iPlan

iPlan

Pinnacle

Calculation algorithm

SuperPosition

Pencil Beam

XVMC

CCCS

Prescription dose

ChildA: 40Gy/5fr

44Gy/4fr

Peripheral: 48Gy/4fr

Peripheral: 48Gy/4fr

 

ChildB: 35Gy/5fr

 

PeriGI:60Gy/8fr

Cenrtral:60Gy/8fr

Prescription point

70% isodose

Isocenter

Isocenter

Isocenter

Beam arrangement

Dynamic conformal arc

Dynamic conformal arc

Static

Static

 

Non-coplanar, 8 arcs

Coplanar, 2 arcs

Non-coplanar, 6–8 beams

Non-coplanar, 6-8 arcs

Respiratory movement

Confined free-breathing(<1cm)

Confined free-breathing

Confined free-breathing

Gated by Abches® or RPM

 

Under abdominal compression

Under abdominal compression

Under abdominal compression

 

Target definition CT

Fusion of LSTCT + dynamic CT

Fusion of 4 times breathing CT

Fusion of 4DCT + breath-hold CT

Breath-hold CT

Planning CT

LSTCT

LSTCT

AveIP from 4DCT

Breath-hold CT

ITV

GTV + 2-6mm

Fusion of 4 times breathing CT

Directly visualized by LSTCT

ITV = GTV

PTV

ITV + 2mm

ITV + CC10mm, AP, LR8mm

ITV + 5mm

ITV + CC8mm, AP, LR5mm

Dose constraints

Liver

V20(include PTV) < 20%

V<16 > 700 cc

V20 < 25% V<15 > 700 cc

V2025%

Spinal cord

Dmax < 25Gy, D1cc < 20Gy

Dmax < 25Gy/4fr

Dmax < 25Gy/4fr

Dmax < 25Gy/4fr

GI tract

Dmax < 25Gy, D1cc < 20Gy

D10cc < 35Gy/4fr

D1cc < 40Gy/4fr, D10cc < 35Gy/4fr

D1cc < 30Gy/4fr, D10cc < 24Gy/4fr

Kidney

-

V20 < 30%

V20 < 30%

D1/3 < 20Gy/4fr

Heart

-

-

-

D1/3 < 28Gy/4fr

Gallbladder

-

-

-

D1/3 < 40Gy/4fr

  1. Abbreviations: TPS, treatment planning system; XVMC, X-ray voxel Monte Carlo algorithm; CCCS, collapsed cone convolution superposition; periGI, perigastrointestinal; RPM, The Varian® Real-time Position Management™ system; GI, gastrointestinal; LSTCT, long scan time computed tomography; 4DCT, 4-dimensional computed tomography; AveIP, average intensity projection; GTV, gross tumor volume; PTV, planning target volume; ITV, internal target volume; CC, cranial and caudal; LRA, left, right and anterior; P, posterior; LR, left and right; AP, anterior and posterior.