Repeated Radionuclide therapy in metastatic paraganglioma leading to the highest reported cumulative activity of 131I-MIBG

Table 1 Treatment response and toxicity.

Tumour lesions	Course of ¹³¹I-MIBG (no.)	Toxicity leukopenia (grade^a)	Response
			Sympt.	Bioch.	Radiol.	TTP^b
three liver mets, one Ln met	1^st	0	PR	PR	PR	33
	2^nd	0	PR	PR	PR	33
	3^rd	2	PR	PR	PR	33
	4^th	1	PR	PR	PR	33
no tumour (CR) after surgery
retroperit. tumour mass, liver and lung mets (< five each)	5^th	0	CR	PR	PR	23
	6^th	1	CR	PR	PR	23
	7^th	1	CR	PR	PR	23
	8^th	0	CR	PR	PR	23
PR in number and size
multiple mets to the lungs, liver, bone, soft tissue, Ln	9^th	0	PR	SD	SD	6
	10^th	0	PR	SD	SD	6

a: common toxicity criteria (CTC); b: time to progression in months; CR: complete response; PR: partial response; SD: stable disease

ISSN: 1748-717X