Figure 7
From: Vascular responses to radiotherapy and androgen-deprivation therapy in experimental prostate cancer
Vascular changes in the transition from untreated (Ctrl), via androgen-deprived (AD), to castration-resistant (CR) disease. Response to androgen-deprivation therapy (ADT) on tumor volumes, showing that CR tumors developed 5.4 ± 0.4 months after ADT ( A). Response to ADT on serum prostate-specific antigen (PSA) expression measured in blood samples withdrawn from the animals ( B). The vascular parameters AUC 1 min and AUC 2 min calculated from semi-quantitative analysis of DCE MRI ( C). The vascular parameters Ktrans and k ep derived from Tofts pharmacokinetic modeling of DCE MRI (D). Significant differences ( p < 0.05) compared to Ctrl tumors are indicated with a *.