Figure 1
From: The combination of olaparib and camptothecin for effective radiosensitization
a. The relationship between concentrations of olaparib and radiosensitizing effects. DLD-1 cells were treated with various concentrations of olaparib for 1 h before radiation and 24 h after radiation. b. The relationship between exposure time (1 h or 24 h) of olaparib and radiosensitizing effects. DLD-1 cells were treated with 1 μM of olaparib for 1 h before radiation and 1 h or 23 h after radiation. c. Clonogenic cell survival assay of H1299 cells with various status of p53 gene. m143, m175, and m248 were made with transfection of mutated p53 gene into codon 143, 175, 248 of H1299 cells, respectively. “Control”: treated with radiation alone; “Olaparib (+)”:treated with radiation and olaparib. Cells were treated with 1 μM of olaparib for 1 h before radiation and 2 h after radiation.