Figure 5

Western blot analysis of DNA damage response in bone marrow cells at 7 d post-radiation. A) Scanned images showing Western blot of p53, Bcl2, and Bax. B) Densitometric quantification of p53, Bcl2, and Bax. *p < 0.002 for p53, < 0.001 for Bax, and < 0.007 for Bcl2 compared to respective radiation+vehicle groups C) Bcl2/Bax ratio. *p < 0.005 compared to radiation+vehicle. D) Western blot images of phospho-ATM and phospho-p53. E) Densitometric quantification of phospho-ATM and phospho-p53. *p < 0.0007 for p-ATM and < 0.0002 for p-p53 compared to radiation+vehicle treated mice. R+V: 5 Gy radiation+vehicle; R: 5 Gy radiation; R+D: 5 Gy radiation+drug (ON 01210.Na).