Table 1 Ki67-expression/Necrosis (%) and Apoptosis (TUNEL test) in RMS xenografts treated with vehicle (DMSO), suberoylanilide hydroxamic acid (SAHA), irradiation (XRT), or SAHA and XRT in the first and second mouse cohort observed day 8 (cohort I) and day 21 (Cohort II)
Treatment | Mean Tumor Age (days) | Mean (SD) Ki-67 (%) | HE (necrosis)(%) | TUNEL (apoptosis) | ||||
|---|---|---|---|---|---|---|---|---|
Cohort I Cohort II | Cohort I CohortII | Cohort I CohortII | Cohort I CohortII | |||||
Control | 39 (± 3) | 37 | 42 (± 16) | 45 (± 12) | 25 (± 11) | 8 (± 6) | 64 (± 9) | 55 (± 9) |
SAHA | 36 (± 1) | 37 | 53 (± 10) | 32 (± 11) | 23 (± 9) | 10 (± 6) | 118 (± 15) | 97 (± 12) |
XRT | 36 (± 1) | 37 | 21 (± 4) | 24 (± 7) | 42 (± 12) | 10 (± 5) | 148 (± 24) | 126 (± 12) |
SAHA + XRT | 36 (± 1) | 37 | 14 (± 8) | 17 (± 4) | 48 (± 17) | 12 (± 6) | 201 (± 11) | 192 (± 10) |