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Figure 1 | Radiation Oncology

Figure 1

From: In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model

Figure 1

Tumor progression of malignant rhabdoid tumor xenografts (MRT) in Cohort I after treatment with ionizing radiation (XRT) or SAHA and XRT. The y-axis plots the multiplication of initial tumor size normalized to the initial size = 1, x-axis plots the time after treatment initiation in days. Figure 1 represents Cohort I and Figure 2 Cohort II. SAHA 100 mg/kg was injected intraperitoneally once daily for 8 consecutive days in Cohort I and for 15 days within 3 weeks in Cohort II starting with day 0. XRT with a single dose of 10 Gy (Cohort I) or with 3 × 3 Gy on three consecutive days (Cohort II) was delivered day 1(-3). After a follow-up of > 40 days, there was a trend towards slower progression in the combined treatment group compared to xenotransplants treated with XRT alone in Cohort I (p = 0.3), and a significant difference in Cohort II.(p < 0.05).

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Radiation Oncology

ISSN: 1748-717X

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