Table 5 Genes from upregulated networks: A number of genes from the data set are associated with breast cancer
From: Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland
Gene | Full name | Role in breast cancer quoted from literature |
|---|---|---|
ACHE | Acetylcholinesterase | “Tumor size was significantly higher when the ACHE gene was amplified in breast cancer.”[11]. |
HSPA1L | heat shock 70kDa protein 1-like | “….HSPA1L and HSPA2 could represent potential biomarkers to follow up the effectiveness of 17AAG in breast cancer”[12]. |
NES | Nestin | “Among the breast cancer subtypes, nestin is highly expressed in basal breast cancer subtype”[13]. |
P2RY2 | purinergic receptor P2Y, G-protein coupled, 2 | “P2Y2 receptor-mediated modulation of estrogen-induced proliferation of breast cancer cells”[14]. |
PLCG1 | phospholipase C, gamma 1 | “Phospholipase Cgamma1 is required for metastasis development and progression”[15]. |
PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | “Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer”[16]. |
PRKCQ | protein kinase C, theta | “PKCtheta promotes c-Rel-driven mammary tumorigenesis in mice”[17]. |
SNTA1 | syntrophin, alpha 1 | “….significant increase in expression of SNTA1 protein compared with the normal tissue was observed in breast carcinoma samples”[18]. |
ALDOA | Aldolase A | “…hypoxia-responsive; prognostic significance in breast cancer”[19]. |
GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | “GNAO1 (Gαo) gene was identified in breast carcinomas and shown to promote oncogenic transformation when introduced into cells”[20]. |
SLC16A3 | solute carrier family 16, member 3 | “Expression of SLC16A3 gene is higher in breast cancer distant metastasis….”[21]. |
TPI1 | triosephosphate isomerase 1 | “Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling”[22]. |
ELL2 | elongation factor, RNA polymerase II, 2 | ELL2 is a Breast Cancer Antioestrogen Resistance (BCAR) 1 gene which control anti-oestrogen-resistant cell growth resistance (BCAR)[23]. |
CCNG1 | cyclin G1 | “We have identified cyclin G as being overexpressed in breast and prostate cancer cells”[24]. |
E2F6 | E2F transcription factor 6 | “E2F6 represses transcription of the brca1, ctip, art27, hp1 α, and the rbap48 genes….”[25]. |
ESRRG | Estrogen-related receptor γ | “Estrogen-related receptor γ modulates cell proliferation and estrogen signaling in breast cancer & ERRγ mRNA was up-regulated dose-dependently by estrogen….”[26]. |
MAPK12 | mitogen-activated protein kinase 12. Also known as ERK3; ERK6; SAPK3; PRKM12; SAPK-3; P38GAMMA | “…elevated expression of p38γ is associated with lower overall survival of patients with breast cancer”[27]. |
HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | The stimulation of HSD17B7 expression by estradiol provides a powerful feed-forward mechanism for estradiol biosynthesis in breast cancer cells[28]. |
TACC2 | transforming, acidic coiled-coil containing protein 2 | “This suggests that increased TACC2 may mediate an oncogenic effect on breast cancer cells and indicates that TACC2 may be a potential therapeutic target”[29]. |
DDX1 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 | “Here, we identify DDX1 RNA overexpression as an independent prognostic marker for early recurrence in primary breast cancer……”[30]. |
MYH1 | myosin, heavy chain 1, skeletal muscle, adult | Recently, MYH1 encoding skeletal muscle myosin heavy polypeptide 1 and MYH9 encoding non-muscle myosin heavy chain type A, were identified as candidate breast cancer genes in systematic analyses of the breast cancer genome[31]. |
UCP1 | uncoupling protein 1 (mitochondrial) | We conclude that UCP1 is up-regulated in breast cancer cell lines and primary breast as well as other tumors[32]. |
PACSIN3 | Protein kinase C and casein kinase substrate in neurons protein 3 | “New targets for breast cancer treatment were identified such as ZONAB, PACSIN3, MRP8 and SUMO1, which have human homologues”[33]. |
PGM1 | phosphoglucomutase 1 | “This gene has been identified as one of the ER status markers in the diagnosis and prognosis of breast cancer patients….”[34]. |
TLN2 | talin 2 | “Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas……”[35]. |
ADIPOR1 | adiponectin receptor 1 | “Variants of the Adiponectin and Adiponectin Receptor 1 Genes and Breast Cancer Risk…”[36]. |
PITX1 | paired-like homeodomain 1 | “The estrogen-regulated transcription factor PITX1 coordinates gene-specific regulation by estrogen receptor-alpha in breast cancer cells…”[37]. |