Table 1 Significant upregulation of pathways involved in cell proliferation, metabolism and breast cancer

Oxidative phosphorylation

4.16

ATP6V0E2, NDUFC1, COX6B1, NDUFS8, COX10, COX5A, NDUFS6, NDUFA12, COX7A1, ATP5G3

Mitochondrial dysfunction

4.06

COX6B1, NDUFS8, COX10, CPT1B, COX5A, TRAK1, NDUFS6, NDUFA12, MAPK12, COX7A1

Breast cancer regulation by Stathmin1

3.81

PPP1R14C, PIK3C2B, E2F6, ADCY2, PRKCQ, CAMK2A, TUBA8, PPM1L, PPP2R5B, TUBA4A, PPP1R3A, TUBA3C/TUBA3D

ERK/MAPK signaling

2.81

PLA2G4E, PPP1R14C, PIK3C2B, TLN2, PLA2G12A, HSPB2, PPM1L, PPP2R5B, PLCG1, PPP1R3A

Cardiac β-adrenergic signaling

2.56

PPP1R14C, ADCY2, PPM1L, PPP2R5B, PDE4A, AKAP6, PPP1R3A, PDE4D

Glycolysis/gluconeogenesis

2.47

PGK1, PGM1, ALDOA, TPI1, Gapdh (includes others), LDHB

Inositol metabolism

2.46

ALDOA, TPI1

Ubiquinone biosynthesis

2.46

NDUFC1, NDUFS8, UFSP1, NDUFS6, NDUFA12

14-3-3-mediated signaling

2.44

PIK3C2B, PRKCQ, TUBA8, TUBA4A, PLCG1, TUBA3C/TUBA3D, MAPK12

Aldosterone signaling in epithelial cells

2.16

PIK3C2B, SACS, PRKCQ, HSPA1L, DNAJC27, HSPB2, PLCG1, DNAJB5

Production of nitric oxide and reactive oxygen species in macrophages

2.14

PPP1R14C, PIK3C2B, PRKCQ, PPM1L, PPP2R5B, PLCG1, PPP1R3A, MAPK12

Fc epsilon RI signaling

2.03

PLA2G4E, PIK3C2B, PRKCQ, PLA2G12A, PLCG1, MAPK12

Endothelin-1 signaling

2.03

PLA2G4E, PIK3C2B, ADCY2, PRKCQ, PLA2G12A, GNAO1, PLCG1, MAPK12

Dopamine receptor signaling

1.96

PPP1R14C, ADCY2, PPM1L, PPP2R5B, PPP1R3A

CCR3 signaling in eosinophils

1.83

PLA2G4E, PIK3C2B, PRKCQ, PLA2G12A, CFL2, MAPK12

Type II diabetes mellitus signaling

1.81

PIK3C2B, RKCQ, PRKAB2, MAPK12, ADIPOR1, KCNJ11

Thrombopoietin signaling

1.75

PIK3C2B, THPO, PRKCQ, PLCG1

CTLA4 signaling in cytotoxic T lymphocytes

1.73

PIK3C2B, AP1S2, PPM1L, PPP2R5B, PLCG1

CDK5 signaling

1.71

PPP1R14C, ADCY2, PPM1L, PPP2R5B, PPP1R3A

TR/RXR activation

1.69

PIK3C2B, RXRG, SLC16A3, UCP1, PPARGC1A

Protein kinase A signaling

1.68

PPP1R14C, ADCY2, PRKCQ, CAMK2A, HIST1H1A, PDE4A, PLCG1, AKAP6, PPP1R3A, TTN, PDE4D

Synaptic long term depression

1.65

PLA2G4E, PRKCQ, PLA2G12A, PPM1L, GNAO1, PPP2R5B

Role of MAPK signaling in the pathogenesis of influenza

1.62

PLA2G4E, PLA2G12A, MAPK12, RABGEF1

Cell cycle regulation by BTG family proteins

1.58

E2F6, PPM1L, PPP2R5B

MIF regulation of innate immunity

1.52

PLA2G4E, PLA2G12A, MAPK12

glioma signaling

1.52

PIK3C2B, E2F6, PRKCQ, CAMK2A, PLCG1

Phenylalanine, tyrosine and tryptophan biosynthesis

1.50

GOT1, GOT2

AMPK signaling

1.48

PIK3C2B, PRKAB2, CPT1B, PPM1L, PPP2R5B, MAPK12

Melatonin signaling

1.46

PRKCQ, CAMK2A, GNAO1, PLCG1

Macropinocytosis signaling

1.44

PIK3C2B, PRKCQ, PLCG1, ITGB6

Cysteine metabolism

1.43

GOT1, GOT2, LDHB

ILK signaling

1.40

PIK3C2B, CFL2, PPM1L, PPP2R5B, MAPK12, ITGB6, MYH1

Protein ubiquitination pathway

1.38

SACS, USP15, HSPA1L, USP13, UBE2B, DNAJC27, HSPB2, USP2, DNAJB5

Corticotropin releasing hormone Signaling

1.32

ADCY2, PRKCQ, GNAO1, PLCG1, MAPK12

HER-2 signaling in breast cancer

1.30

PIK3C2B, PRKCQ, PLCG1, ITGB6