Figure 10
From: Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland
The downregulated networks may accelerate cellular transformation. A) The top downregulated network has TGFβ as the nodal molecule and downregulation of at least 8 genes (ARHGAP17, BAMBI, BCL9, BRCC3, CELSR2, NAB2, PRKCB, SEMA4D) in the network facilitates carcinogenesis. B) The second downregulated network has 6 genes (ACPP, GPRC5A, KIT, LYN, MAP2, and TDGF1) which may paly a role in cellular transformation.