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Table 4 Predictors of local control, overall and colostomy-free survival in univariate analysis (n= 51)

From: Does gap-free intensity modulated chemoradiation therapy provide a greater clinical benefit than 3D conformal chemoradiation in patients with anal cancer?

 

Overall survival

Locoregional relapse-free survival

Colostomy-free survival

 

HR

CI 95%

p-value

HR

CI 95%

p-value

HR

CI 95%

p-value

WHO

         

0

1

[0.99-7.17]

0.053

1

[0.83-5.64]

0.115

1

[1.3-8.07]

0.012

1/2

2.66

  

2.16

  

3.24

  

T Stage

         

T1/T2/in situ

1

[0.45-3.42]

0.684

1

[0.38-2.64]

1

1

[0.44-2.73]

0.846

T3/T4

1.23

  

1

  

1.1

  

N Stage

         

N0

1

[0.95-7.5]

0.062

1

[0.97-7.46]

0.057

1

[1.04-6.91]

0.042

N1/N2/N3

2.67

  

2.69

  

2.68

  

Histology

         

Squamous cell cancer other

1 0.86

[0.2-3.82]

0.846

1 0.83

[0.19-3.65]

0.809

1 0.68

[0.16-2.97]

0.612

Treatment duration

         

<56 days

1

[0.26-1.96]

0.511

1

[0.23-1.60]

0.317

1

[0.23-1.49]

0.262

>56 days

0.71

  

0.61

  

0.59

  

Total dose

         

<50 Gy

1

[0.11-6.47]

0.874

1

[0.14-8.09]

0.951

1

[0.04-0.88]

0.033

>50 Gy

0.85

  

1.07

  

0.19

  

Technique

         

3D-CRT

1

[0.46-3.94]

0.580

1

[0.55-3.98]

0.431

1

[0.81-5.66]

0.125

IMRT

1.35

  

1.48

  

2.14

  

Treatment breaks for toxicity

         

Yes

1

[0.23-4.46]

0.996

1

[0.37-4.56]

0.680

1

[0.16-2.96]

0.607

No

1

  

1.3

  

0.68

  

Planned gap

         

Yes

1

[0.29-3.17]

0.943

1

[0.3-2.4]

0.765

1

[0.37-3.17]

0.882

No

0.96

  

0.85

  

1.08

  

Pelvic radiotherapy

         

Yes

1

[0.34-3.33]

0.905

1

[0.44-5.35]

0.501

1

[0.45-4.1]

0.587

No

1.07

  

1.54

  

1.36