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Table 4 Mean values and standard deviations of parameters that evaluate the contours generated by the three software, before and after the manual correction, for each organ of the mesothelioma patients

From: Systematic evaluation of three different commercial software solutions for automatic segmentation for adaptive therapy in head-and-neck, prostate and pleural cancer

  AA MA VA AM MM VM p value
CTV
DSC, (SD) 0.85 (0.02) 0.86 (0.02) 0.85 (0.02) 0.85 (0.02) 0.94 (0.04) 0.91 (0.02) + ^
Sensitivity. (SD) 0.92 (0.03) 0.90 (0.02) 0.91 (0.02) 0.92 (0.03) 0.93 (0.03) 0.94 (0.03) * ° ^
IncI. (SD) 0.79 (0.02) 0.82 (0.02) 0.80 (0.02) 0.80 (0.02) 0.95 (0.06) 0.87 (0.02) * ° + ^ =
ΔV (%). (SD) 15.54 (1.53) 9.26 (2.06) 13.48 (2.45) 14.90 (1.45) −1.78 (4.95) 8.10 (3.04) * ° + ^ =
Δx (mm). (SD) 3.42 (4.20) 3.42 (2.79) 4.10 (2.24) 4.20 (4.24) 0.98 (1.24) 3.40 (2.51) =
Δy (mm). (SD) 3.82 (3.60) 3.92 (3.61) 3.52 (3.90) 3.54 (3.69) 1.78 (1.56) 2.36 (1.51)  
Δz (mm). (SD) 4.00 (4.87) 4.00 (4.87) 4.50 (4.80) 4.00 (3.35) 0.50 (1.12) 0.00 (0.00) ^
Contra lateral lung
DSC. (SD) 0.95 (0.03) 0.94 (0.03) 0.94 (0.02) 0.97 (0.01) 0.98 (0.01) 0.99 (0.01) ^ =
Sensitivity. (SD) 0.93 (0.05) 0.90 (0.06) 0.92 (0.04) 0.97 (0.01) 0.97 (0.01) 0.99 (0.01) ° ^ =
IncI. (SD) 0.97 (0.02) 0.99 (0.01) 0.96 (0.020) 0.97 (0.02) 0.98 (0.03) 0.99 (0.01) * °
ΔV (%). (SD) −4.66 (5.16) −8.68 (6.59) −4.16 (5.43) 0.14 (3.36) −1.24 (3.51) −0.52 (0.98) * °
Δx (mm). (SD) 0.70 (0.67) 0.40 (0.55) 0.88 (1.43) 1.48 (2.22) 0.60 (0.42) 0.00 (0.00)  
Δy (mm). (SD) 2.46 (2.59) 2.46 (2.59) 2.24 (2.50) 1.30 (0.67) 0.90 (0.96) 0.00 (0.00) ^
Δz (mm). (SD) 7.50 (7.07) 7.50 (7.07) 10.00 (7.91) 1.88 (3.75) 1.88 (3.75) 0.00 (0.00)  
Esophagus
DSC. (SD) 0.68 (0.08) 0.67 (0.08) 0.62 (0.03) 0.69 (0.08) 0.83 (0.12) 0.76 (0.02) # °
Sensitivity. (SD) 0.78 (0.08) 0.69 (0.10) 0.73 (0.09) 0.79 (0.08) 0.80 (0.13) 0.84 (0.07) * #
IncI. (SD) 0.61 (0.13) 0.67 (0.13) 0.54 (0.07) 0.62 (0.13) 0.86 (0.12) 0.70 (0.06) * ° + =
ΔV (%). (SD) 32.92 (31.51) 6.80 (25.74) 37.98 (28.67) 33.46 (32.52) −5.98 (11.80) 21.22 (17.13) * ° + =
Δx (mm). (SD) 3.82 (2.46) 2.36 (1.84) 2.92 (2.49) 3.34 (1.87) 1.30 (0.76) 1.40 (0.55) ^
Δy (mm). (SD) 2.74 (2.78) 2.54 (2.84) 2.26 (2.33) 2.74 (2.77) 1.18 (1.81) 2.16 (2.92)  
Δz (mm). (SD) 7.50 (7.29) 8.00 (6.94) 7.00 (6.47) 7.50 (7.29) 5.00 (7.32) 5.50 (7.37) +
Heart
DSC. (SD) 0.88 (0.03) 0.87 (0.05) 0.88 (0.05) 0.90 (0.01) 0.94 (0.01) 0.95 (0.01) + ^
Sensitivity. (SD) 0.86 (0.09) 0.82 (0.10) 0.86 (0.10) 0.89 (0.06) 0.93 (0.03) 0.94 (0.02) * ° ^
IncI. (SD) 0.91 (0.04) 0.93 (0.04) 0.90 (0.03) 0.91 (0.05) 0.96 (0.04) 0.96 (0.02) * ^
ΔV (%). (SD) −4.48 (14.19) −11.40 (13.81) −4.58 (14.07) −1.50 (11.80) −2.30 (6.80) −2.02 (4.08) * °
Δx (mm). (SD) 1.26 (1.04) 1.18 (0.80) 1.20 (0.45) 1.38 (0.99) 0.80 (0.45) 1.58 (0.93)  
Δy (mm). (SD) 1.78 (1.22) 1.58 (1.26) 1.76 (1.48) 1.86 (1.25) 1.08 (1.10) 1.28 (0.72)  
Δz (mm). (SD) 2.50 (1.77) 3.50 (2.85) 3.50 (2.24) 3.00 (2.09) 1.50 (1.37) 2.00 (2.09)  
Intestine
DSC. (SD) 0.77 (0.13) 0.74 (0.15) 0.77 (0.13) 0.87 (0.03) 0.93 (0.04) 0.93 (0.02) + ^
Sensitivity. (SD) 0.75 (0.21) 0.68 (0.21) 0.74 (0.21) 0.90 (0.05) 0.90 (0.06) 0.95 (0.01) * ° ^
IncI. (SD) 0.85 (0.09) 0.86 (0.08) 0.84 (0.10) 0.86 (0.07) 0.97 (0.03) 0.92 (0.04) * ° + ^ =
ΔV (%). (SD) −9.54 (30.30) −19.36 (29.33) −9.7 (31.47) 5.46 (14.22) −7.48 (5.73) 2.98 (5.13) * ° + =
Δx (mm). (SD) 2.94 (1.36) 4.90 (4.77) 4.52 (5.51) 2.08 (1.21) 1.58 (1.05) 1.08 (1.10) ^
Δy (mm). (SD) 4.12 (4.23) 4.20 (4.05) 4.70 (3.83) 1.86 (1.55) 1.48 (0.67) 1.86 (2.54)  
Δz (mm). (SD) 11.50 (8.40) 12.00 (7.37) 12.00 (7.16) 3.00 (4.11) 0.00 (0.00) 1.00 (1.37)  
Liver
DSC. (SD) 0.93 (0.02) 0.93 (0.03) 0.90 (0.01) 0.93 (0.03) 0.97 (0.02) 0.95 (0.02) # ° +
Sensitivity. (SD) 0.92 (0.02) 0.90 (0.03) 0.92 (0.03) 0.93 (0.03) 0.95 (0.03) 0.96 (0.02) ^
IncI. (SD) 0.93 (0.03) 0.95 (0.04) 0.88 (0.02) 0.93 (0.03) 0.98 (0.02) 0.94 (0.03) * # ° + =
ΔV (%). (SD) −0.80 (2.10) −5.08 (2.16) 5.44 (4.93) 0.00 (2.29) −2.96 (2.41) 2.26 (4.28) * ° + =
Δx (mm). (SD) 3.24 (2.53) 2.64 (1.81) 3.80 (2.26) 2.16 (1.90) 0.60 (0.65) 0.70 (0.45)  
Δy (mm). (SD) 1.28 (1.11) 1.56 (1.09) 1.38 (0.70) 1.18 (1.27) 0.60 (0.55) 1.00 (0.70)  
Δz (mm). (SD) 1.50 (2.24) 3.50 (2.85) 4.50 (3.26) 2.50 (1.77) 1.00 (1.37) 1.00 (1.37)  
Kidney left
DSC. (SD) 0.89 (0.02) 0.87 (0.03) 0.81 (0.06) 0.91 (0.01) 0.95 (0.02) 0.92 (0.02) * # ° =
Sensitivity. (SD) 0.88 (0.05) 0.84 (0.06) 0.81 (0.12) 0.93 (0.02) 0.92 (0.03) 0.91 (0.02) * #
IncI. (SD) 0.89 (0.02) 0.90 (0.03) 0.82 (0.04) 0.88 (0.02) 0.98 (0.03) 0.93 (0.04) * # ° + =
ΔV (%). (SD) −0.98 (7.21) −7.40 (8.71) −1.40 (15.64) 4.90 (4.36) −6.08 (3.41) −1.10 (5.61) * +
Δx (mm). (SD) 0.90 (0.74) 1.10 (0.65) 1.30 (0.57) 0.80 (0.57) 0.50 (0.50) 1.00 (0.79)  
Δy (mm). (SD) 0.60 (0.42) 0.70 (0.84) 1.18 (1.11) 0.40 (0.22) 0.20 (0.27) 0.50 (0.36)  
Δz (mm). (SD) 2.00 (1.12) 4.00 (2.85) 6.50 (5.18) 1.50 (1.37) 0.00 (0.00) 0.00 (0.00)  
Kidney right
DSC. (SD) 0.89 (0.02) 0.86 (0.04) 0.83 (0.05) 0.91 (0.02) 0.95 (0.02) 0.93 (0.01) #
Sensitivity. (SD) 0.88 (0.04) 0.83 (0.06) 0.81 (0.10) 0.93 (0.03) 0.91 (0.03) 0.92 (0.02) #
IncI. (SD) 0.90 (0.05) 0.91 (0.05) 0.86 (0.09) 0.89 (0.05) 0.99 (0.02) 0.94 (0.02) # ° + ^ =
ΔV (%). (SD) −1.92 (9.47) −8.68 (8.81) −4.30 (17.24) 4.28 (7.74) −7.72 (1.43) −2.46 (3.08) + ^ =
Δx (mm). (SD) 1.46 (1.13) 1.06 (1.24) 1.10 (0.74) 0.80 (0.76) 0.60 (0.42) 0.50 (0.71)  
Δy (mm). (SD) 0.60 (0.55) 0.70 (0.45) 1.08 (1.70) 0.60 (0.55) 0.50 (0.35) 0.80 (0.57)  
Δz (mm). (SD) 3.50 (2.85) 3.00 (4.11) 5.00 (6.37) 1.00 (1.37) 0.50 (1.12) 0.50 (1.12)  
Spinal cord
DSC. (SD) 0.71 (0.07) 0.69 (0.08) 0.74 (0.06) 0.73 (0.04) 0.83 (0.02) 0.86 (0.05) # ° ^
Sensitivity. (SD) 0.65 (0.15) 0.61 (0.16) 0.74 (0.16) 0.69 (0.12) 0.72 (0.18) 0.85 (0.11) * # ° ^
IncI. (SD) 0.82 (0.15) 0.85 (0.13) 0.78 (0.12) 0.83 (0.14) 1.00 (0.00) 0.88 (0.06) * # ° + =
ΔV (%). (SD) −15.72 (32.61) −24.9 (31.50) −0.72 (34.59) −12.86 (31.11) −27.76 (18.01) −3.02 (16.70) * # ° =
Δx (mm). (SD) 1.00 (0.61) 0.80 (0.27) 0.40 (0.42) 1.00 (0.61) 0.30 (0.45) 0.40 (0.65)  
Δy (mm). (SD) 4.70 (5.93) 4.40 (4.90) 4.02 (4.06) 4.70 (5.93) 0.80 (0.67) 0.2 (0.27)  
Δz (mm). (SD) 22.00 (23.21) 22.00 (22.87) 21.50 (21.84) 9.00 (8.94) 3.00 (4.11) 1.00 (2.24)  
Spleen
DSC. (SD) 0.92 (0.01) 0.90 (0.03) 0.84 (0.04) 0.93 (0.01) 0.95 (0.02) 0.94 (0.01) # ° =
Sensitivity. (SD) 0.90 (0.00) 0.86 (0.03) 0.88 (0.02) 0.92 (0.01) 0.92 (0.02) 0.94 (0.01) ^
IncI. (SD) 0.93 (0.02) 0.96 (0.03) 0.80 (0.06) 0.94 (0.01) 0.99 (0.02) 0.93(0.03) * # ° +
ΔV (%). (SD) −3.85 (2.04) −10.38 (2.89) 9.90 (10.45) −3.00 (1.12) −6.73 (1.16) 1.18 (4.04) * +
Δx (mm). (SD) 0.75 (0.65) 0.88 (0.48) 1.00 (0.41) 1.48 (0.78) 0.50 (0.00) 0.75 (0.64)  
Δy (mm). (SD) 2.58 (2.89) 2.95 (2.61) 3.58 (3.49) 1.73 (1.51) 1.00 (0.58) 1.75 (0.29)  
Δz (mm). (SD) 2.50 (2.04) 1.88 (2.93) 3.75 (2.23) 1.25 (1.44) 0.00 (0.00) 1.88 (2.39)  
  1. For automatic segmentation: *AA vs. MA: p<0.043, #AA vs. VA: p<0.043, °MA vs. VA: p<0.043.
  2. For automatic segmentation+ manual correction: +AM vs. MM: p<0.043, ^AM vs. VM: p<0.043, =MM vs. VM: p<0.043.
  3. Abbreviations: CTV = Clinical target volume; SD = Standard deviation, DSC = DICE similarity coefficient, IncI = inclusiveness index, AA = Abas Automatic, MA = MiM Automatic, VA = Velocity Automatic, AM = Abas Manual Correction, MM = MiM Manual Correction, VM = Velocity Manual Correction.