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Table 2 Univariate and multivariate analyses of factors associated with survival in a cohort of 84 unresectable stage III non-small-cell lung cancer patients

From: FDG uptake correlates with recurrence and survival after treatment of unresectable stage III non-small cell lung cancer with high-dose proton therapy and chemotherapy

Variable LRFS DMFS PFS OS
  HR 95% CI p HR 95% CI p HR 95%CI p HR 95%CI p
Univariate analyses         
Age (< 70 vs ≥ 70 years) 0.837,0.425-1.652 0.609 0.820,0.417-1.615 0.566 0.792,0.402-1.560 0.500 0.902,0.456-1.783 0.766
Gender (female vs male) 1.238,0.606-2.532 0.558 1.283,0.628-2.623 0.495 1.253,0.612-2.564 0.538 1.107,0.538-2.275 0.782
KPS (< 90 vs ≥ 90) 0.479,0.245-0.938 0.032 0.496,0.253-0.971 0.041 0.509,0.260-0.996 0.049 0.424,0.216-0.831 0.012
Smoking history(Yes vs No) 0.249,0.034-1.822 0.171 0.236,0.032-1.726 0.155 0.260,0.036-1.902 0.185 0.249,0.034-1.822 0.171
Histology (SCCvs Adeno) 0.593,0.287-1.223 0.157 0.556,0.270-1.147 0.112 0.538,0.261-1.111 0.094 0.637,0.309-1.313 0.222
GTV, cm3 (<96.6 vs ≥ 96.6) 1.664,0.817-3.309 0.163 1.718,0.855-3.453 0.129 1.734,0.863-3.483 0.122 1.764,0.866-3.592 0.118
Lung V20 (26.2 < vs ≥26.2) 1.057,0.544-2.053 0.871 0.967,0.497-1.881 0.921 1.002,0.515-1.947 0.996 1.005,0.517-1.955 0.989
MLD (1797.1 < vs ≥1797.1) 1.489,0.744-2.979 0.260 1.522,0.767-3.018 0.229 1.528,0.771-3.031 0.225 1.489,0.744-2.979 0.260
SUV1 (< 14.2 vs ≥ 14.2) 3.029,1.426-6.432 0.004 3.204,1.504-6.827 0.003 3.269,1.529-6.992 0.002 2.670,1.251-5.699 0.011
SUV2 (< 3.6 vs ≥ 3.6) 3.823,1.646-8.881 0.002 3.998,1.718-9.229 0.001 3.877,1.666-9.021 0.002 3.297,1.414-7.686 0.006
ΔSUV (< 9.4 vs ≥ 9.4) 1.372,0.649-2.899 0.407 1.575,0.745-3.332 0.235 1.721,0.812-3.646 0.156 1.366,0.646-2.889 0.414
ΔSUV/SUV1 (< 0.68 vs ≥ 0.68) 0.652,0.308-1.381 0.264 0.714,0.337-1.511 0.378 0.767,0.363-1.623 0.488 0.807,0.377-1.726 0.580
Multivariate analyses         
KPS (< 90 vs ≥ 90) 0.409,0.188-0.893 0.025 0.419,0.189-0.929 0.032 0.413,0.187-0.912 0.029 0.291,0.130-0.651 0.003
SUV1 (< 14.2 vs ≥ 14.2) 2.304,0.994-5.337 0.052 2.576,1.098-6.041 0.030 2.620,1.115-6.158 0.027 2.347,1.006-5.474 0.048
SUV2 (< 3.6 vs ≥ 3.6) 2.947,1.213-7.161 0.017 2.892,1.195-7.001 0.019 2.792,1.155-6.750 0.023 2.620,1.083-6.342 0.033
  1. Abbreviations: LRFS = local recurrence free survival; DMFS = distant metastasis free survival; PFS = progress free survival; OS = overall survival; HR = hazard ration; CI = confidence interval; KPS = Karnofsky Performance Status; SCC = squamous cell carcinoma; Adeno = adenocarcinoma; GTV = gross tumor volume; MLD = mean lung dose; SUV = standardized uptake values.