|
Structure, DVH dose level (Gy)
|
Photons
|
Protons
|
P value, Wilcoxian Signed Rank test
|
Significance level
|
Sequential Bonferroni
|
|---|
|
Mean
|
SD
|
Mean
|
SD
|
|---|
|
Esophagus
| | | | | | | |
|
20
|
65.87
|
23.54
|
3.89
|
7.68
|
9.82E-05
|
<0.01
|
†
|
|
15
|
96.68
|
5.12
|
8.73
|
12.53
|
9.80E-05
|
<0.01
|
†
|
|
10
|
98.09
|
3.26
|
14.76
|
16.59
|
9.75E-05
|
<0.01
|
†
|
|
5
|
99.61
|
0.98
|
24.67
|
21.28
|
9.80E-05
|
<0.01
|
†
|
|
Heart
| | | | | | | |
|
20
|
2.80
|
4.58
|
0.03
|
0.08
|
2.51E-04
|
<0.01
|
†
|
|
15
|
42.49
|
16.98
|
0.15
|
0.23
|
9.82E-05
|
<0.01
|
†
|
|
10
|
56.77
|
11.12
|
0.53
|
0.62
|
9.82E-05
|
<0.01
|
†
|
|
5
|
60.68
|
11.30
|
1.31
|
1.28
|
9.82E-05
|
<0.01
|
†
|
|
Kidneys
| | | | | | | |
|
20
|
2.03
|
1.91
|
0.60
|
0.82
|
3.15E-03
|
<0.01
|
†
|
|
15
|
4.11
|
2.81
|
2.49
|
2.34
|
1.07E-03
|
<0.01
|
†
|
|
10
|
5.92
|
3.68
|
5.53
|
4.70
|
2.50E-01
|
NS
|
—
|
|
5
|
8.89
|
4.95
|
10.58
|
7.95
|
6.24E-01
|
NS
|
—
|
|
Liver
| | | | | | | |
|
20
|
3.09
|
3.17
|
0.08
|
0.15
|
9.82E-05
|
<0.01
|
†
|
|
15
|
14.69
|
4.22
|
0.27
|
0.30
|
9.82E-05
|
<0.01
|
†
|
|
10
|
22.55
|
1.99
|
0.61
|
1.05
|
9.82E-05
|
<0.01
|
†
|
|
5
|
24.78
|
3.95
|
1.10
|
0.75
|
9.82E-05
|
<0.01
|
†
|
|
Lungs
| | | | | | | |
|
20
|
3.07
|
2.14
|
2.27
|
1.92
|
3.54E-02
|
< 0.05
|
*
|
|
15
|
6.03
|
2.92
|
4.87
|
3.24
|
6.14E-03
|
< 0.01
|
†
|
|
10
|
8.35
|
3.52
|
7.66
|
4.32
|
7.23E-02
|
NS
|
—
|
|
5
|
11.69
|
4.51
|
11.31
|
5.52
|
1.53E-01
|
NS
|
—
|
|
Thyroid
| | | | | | | |
|
20
|
11.91
|
21.19
|
0.00
|
0.00
|
6.10E-05
|
<0.01
|
†
|
|
15
|
66.16
|
30.19
|
0.00
|
0.00
|
9.80E-05
|
<0.01
|
†
|
|
10
|
80.97
|
21.53
|
0.00
|
0.00
|
9.48E-05
|
<0.01
|
†
|
|
5
|
92.50
|
10.68
|
0.51
|
0.76
|
9.65E-05
|
<0.01
|
†
|
- Note: The table lists mean V20, V15, V10, and V5 and standard deviation (SD) values for the esophagus, heart, kidneys, liver, lungs, and thyroid. Statistical results from the Wilcoxon signed rank test (i.e., p-value for 1-tailed Wilcoxon signed rank test) are listed. Results from the sequential Bonferroni procedure are also included; † and * indicate differences were significant at the 0.01 and 0.05 levels, respectively.
- For this study 5, 10, 15, and 20 Gy are equivalent to 21.4%, 42.7%, 64.1%, and 85.5% of the prescribed dose, respectively.
