Incidence and development of acute GI/GU toxicity from pretreatment symptoms | |||||||||
---|---|---|---|---|---|---|---|---|---|
 |  | Acute GI toxicity | Acute GU toxicity | ||||||
 |  | WP | PO | WP | PO | ||||
Pretreatment Symptoms | Acute toxicity | n | % | n | % | n | % | n | % |
0 → 0 | 33 | 28.45% | 40 | 49.38% | 43 | 37.07% | 36 | 44.44% | |
0 → 1 | 14 | 12.07% | 17 | 20.99% | 18 | 15.52% | 12 | 14.81% | |
0 → 2 | 58 | 50.00% | 20 | 24.69% | 25 | 21.55% | 17 | 20.99% | |
0 → 3 | 1 | 0.86% |  |  | 1 | 0.86% |  |  | |
1 → 0 |  |  | 1 | 1.23% | 13 | 11.21% | 7 | 8.64% | |
1 → 1 |  |  | 2 | 2.47% | 6 | 5.17% | 3 | 3.70% | |
1 → 2 | 5 | 4.31% | 1 | 1.23% | 4 | 3.45% | 3 | 3.70% | |
1 → 3 | 2 | 1.72% |  |  |  |  |  |  | |
2 → 0 | 1 | 0.86% |  |  | 1 | 0.86% | 1 | 1.23% | |
2 → 1 |  |  |  |  |  |  | 1 | 1.23% | |
2 → 2 | 1 | 0.86% |  |  | 1 | 0.86% |  |  | |
2 → 3 |  |  |  |  | 2 | 1.72% | 1 | 1.23% | |
3 → 0 |  |  |  |  | 1 | 0.86% |  |  | |
3 → 1 |  |  |  |  |  |  |  |  | |
3 → 2 | 1 | 0.72% |  |  |  |  |  |  | |
3 → 3 |  |  |  |  | 1 | 0.86% |  |  | |
Development of late GI/GU toxicity from acute GI/GU toxicity | |||||||||
 |  | GI toxicity | GU toxicity | ||||||
 |  | WP | PO | WP | PO | ||||
Acute toxicity | Late toxicity | n | % | n | % | n | % | n | % |
0 → 0 | 29 | 25.00% | 34 | 41.98% | 41 | 35.34% | 31 | 38.27% | |
0 → 1 | 5 | 4.31% | 5 | 6.17% | 13 | 11.21% | 8 | 9.88% | |
0 → 2 |  |  | 2 | 2.47% | 1 | 0.86% | 3 | 3.70% | |
0 → 3 | 1 | 0.86% |  |  | 3 | 2.59% | 2 | 2.47% | |
1 → 0 | 10 | 8.62% | 11 | 13.58% | 17 | 14.66% | 9 | 11.11% | |
1 → 1 | 4 | 3.45% | 7 | 8.64% | 4 | 3.45% | 2 | 2.47% | |
1 → 2 |  |  |  |  | 1 | 0.86% | 2 | 2.47% | |
1 → 3 |  |  | 1 | 1.23% | 2 | 1.72% | 3 | 3.70% | |
2 → 0 | 47 | 40.52% | 9 | 11.11% | 18 | 15.52% | 10 | 12.35% | |
2 → 1 | 9 | 7.76% | 6 | 7.41% | 8 | 6.90% | 8 | 9.88% | |
2 → 2 | 5 | 4.31% | 5 | 6.17% | 3 | 2.59% | 2 | 2.47% | |
2 → 3 | 2 | 1.72% | 1 | 1.23% | 1 | 0.86% |  |  | |
2 → 4 | 1 | 0.86% |  |  |  |  |  |  | |
3 → 0 | 2 | 1.72% |  |  |  |  |  |  | |
3 → 1 | 1 | 0.86% |  |  | 2 | 1.72% |  |  | |
3 → 2 |  |  |  |  | 1 | 0.86% |  |  | |
3 → 3 |  |  |  |  | 1 | 0.86% | 1 | 1.23% | |
Summary of last late GI/GU toxicities dynamics | |||||||||
 |  |  |  |  |  | WP | PO | ||
Last late GI toxicity | n | % | n | % | |||||
Patients without toxicity | 29 | 25.00% | 34 | 41.98% | |||||
Decrease of toxicity (G1,2,3→G0) | 59 | 50.86% | 20 | 24.69% | |||||
Patients with moderate toxicity-G1 | Â | Â | Â | Â | |||||
   Development G0 → G1 | 5 | 4.31% | 5 | 6.17% | |||||
   Unchanged grade of toxicity G1 | 4 | 3.45% | 7 | 8.64% | |||||
   Decrease of toxicity from G2, 3→ G1 | 10 | 8.62% | 6 | 7.41% | |||||
Patients with high level toxicity G2, 3, 4 | 9 | 7.76% | 9 | 11.11% | |||||
 |  |  |  |  |  | WP | PO | ||
Last late GU toxicity | n | % | n | % | |||||
Patients without toxicity | 41 | 35.34% | 31 | 38.27% | |||||
Decrease of toxicity (G1,2,3 → G0) | 35 | 30.17% | 19 | 23.46% | |||||
Patients with moderate toxicity-G1 | Â | Â | Â | Â | |||||
   Development G0 → G1 | 13 | 11.21% | 8 | 9.88% | |||||
   Unchanged grade of toxicity G1 | 4 | 3.45% | 2 | 2.47% | |||||
   Decrease of toxicity from G2, 3→G1 | 10 | 8.62% | 8 | 9.88% | |||||
Patients with high level toxicity G2, 3, 4 | 13 | 11.21% | 13 | 16.05% |